TGen researchers map potential genetic origin...lung cancer in nonsmokers


Study presented at AACR-IASLC conference of multiple novel mutations and pathway changes not found in patients with lung cancer who smoked
SAN DIEGO — Jan. 9, 2012 — Researchers at the Translational Genomics Research Institute (TGen) have begun to identify mutations and cellular pathway changes that lead to lung cancer in never-smokers — a first step in developing potential therapeutic targets.
“This is the starting point. We certainly have a lot of pathways and gene expression alterations that we’re going to be very interested in confirming and looking at in larger cohorts of patients,” said Dr. Timothy G. Whitsett, Senior Postdoctoral Fellow in TGen’s Cancer and Cell Biology Division.
Whitsett presented the findings today at the American Association for Cancer Research (AACR) and International Association for the Study of Lung Cancer (IASLC) Joint Conference on Molecular Origins of Lung Cancer: Biology, Therapy and Personalized Medicine, held Jan. 8-11, 2012, at the San Diego Marriott Marina & Hotel.
“This is a very important subset of patients with lung cancer, and our research looks to identify pathways and genes that are potentially driving this cancer,” said Dr. Whitsett, who works under Dr. Nhan Tran, head of TGen’s CNS Tumor Research Lab. The title of the abstract Dr. Whitsett presented is Identification of key tumorigenic pathways in never-smoker lung adenocarcinoma patients using massively parallel DNA and RNA sequencing.
Never-smokers are defined for this study as individuals who smoked less than 100 cigarettes in their lifetime. About 10 percent of lung cancer cases occur in this patient population, which researchers have not examined as extensively as they have studied patients with lung cancer who smoked,... .


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Jean, please do many of us a favor and get rid of this thread. If anyone really cared, especially all of the so called anti-smoking glee clubs, then they would be fighting against our Government to take cigarettes off the market instead of making billions of dollars off of it by constantly spreading around implied lies about secondary smoke from a cigarette. The bottom line is, is that CARS, Diesel Trucks etc. are destroying this environment not a "friggand" cigarette butt. I am a non-smoker that is sick and tired off all of this bull crap about cigarettes. First of all, they made it legal to smoke cigarettes so the bottom line is it's none of your business if anyone smokes. Do you drive a car? The second thing is that POT contains the same and MORE CONCENTRATED cancer causing chemicals in it than cigarettes and these same "game players" have nothing to say about the passage of POT. I wish these attention, discrimination and money making games would stop. If anyone needs attention then join the Circus and quit creating highly discriminating and very dangerous threads against cigarette smokers that are legally smoking cigarettes because who knows, some idiot, may KILL SMOKERS BECAUSE OF THIS THREAD (carpet rodent -very discriminating title.) Is it possible that a smoker may be killed because of this thread? I'm not joking Please get rid of this thread before someone is serious hurt from it.
I can just visualize someone thrown off of a balcony for smoking a cigarette because some idiot saw that very dangerous and life threatening commercial, in my opinion, on TV about UNCONCENTRATED CIGARETTE SMOKE KILLING AN INFANT WHICH WE KNOW IS VIRTUALLY IMPOSIBLE TO HAPPEN BUT THE VIEWER MAY BELIEVE THIS DANGEROUS CRAP and murder someone because of it.
This crap is getting way out of control. Again, I AM A NON-SMOKER that is sick and tired of all of this dangerous "shit" that is going on. Please take this thread off this site now before someone is KILLED due to it. Enough is enough!
I am sorry for this email but I remember a young woman that was stabbed, some years ago, in her lung in an elevator in San Francisco because she was smoking a cigarette in an elevator. SMOKING IS NOT A DEATH SENTENCE! By the way, the Stabber was smoking a "joint" at the time. Doesn't make sense now, does it?

Thank you.

I suppose every little helps.
But isn’t it so that knowledge can be shared, but experience can not?
Still, after 12 smoke free years I can have the urge … Some powerful addiction with a long tail so to speak.
You dug deep for this one, SekeRobb****
- I hope I'm not OT