Index | Recent Threads | Unanswered Threads | Who's Active | Guidelines | Search |
![]() |
World Community Grid Forums
![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
No member browsing this thread |
Thread Status: Active Total posts in this thread: 123
|
![]() |
Author |
|
l_mckeon
Senior Cruncher Joined: Oct 20, 2007 Post Count: 439 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
ALS and gut bacteria linked in “remarkable” new Harvard study
Mutations in a gene called C9orf72 account for more familial cases of ALS than any other genetic variant. ALS is generally thought to be caused by a relatively equal balance of genetic and environmental factors and, although researchers have homed in on a number of particular genetic variants that can be associated with the disease, it is still unknown what particular environmental elements play a role. This new research stemmed from an initial unexpected observation. Mice bred with C9orf72 mutations designed to model ALS displayed significantly different health effects at two separate locations. “Many of the inflammatory characteristics that we observed consistently and repeatedly in our Harvard facility mice weren’t present in the Broad facility mice,” explains lead author of the new study, Aaron Burberry. “Even more strikingly, the Broad facility mice survived into old age. After investigating a number of potential variables that could account for these substantially different health outcomes, the researchers focused in on differences in the animal’s microbial flora as the possible primary factor. DNA sequencing indeed confirmed a number of microbial differences between the two cohorts of mice, despite similar lab conditions. [Similar findings from further investigations with other labs etc.] More at: https://newatlas.com/science/als-gut-bacteria-microbiome-harvard-study/ |
||
|
l_mckeon
Senior Cruncher Joined: Oct 20, 2007 Post Count: 439 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Gut bacteria signature reveals liver disease with over 90% accuracy
This set of [19 from fecal sampling] bacterial species was associated with a cirrhosis diagnosis with an accuracy of 94 percent, and the team says it could also be used to determine the stage of liver fibrosis. With these exciting results, the team then set about verifying the technique on a pair of independent patient groups in China and Italy. Here it again proved highly accurate, correctly identifying cirrhosis in more than 90 percent of patients. Much more at: https://newatlas.com/medical/gut-bacteria-advanced-liver-disease-accuracy/ |
||
|
Jim Slade
Veteran Cruncher Joined: Apr 27, 2007 Post Count: 665 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
The Microbiome in Mood Disorders Carlat Reports / Carlat Publishing
The mind-gut connection is implicated in psychiatric disorders from autism to schizophrenia, and the International Society for Bipolar Disorders 2020 conference featured a review of this research in bipolar and depression. https://www.thecarlatreport.com/blog/the-microbiome-in-mood-disorders/ ![]() |
||
|
ThreadRipper
Veteran Cruncher Sweden Joined: Apr 26, 2007 Post Count: 1322 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Specific gut bacteria may reduce severity of Parkinson's disease Compelling new research is again pointing to the role of the microbiome and gut bacteria in the progression of Parkinson’s disease. A study published in the journal Cell Reports describes how a particular probiotic bacterium may have the ability to prevent the abnormal accumulation of a protein commonly associated with the neurological damage seen in the disease. [. . . ] One particular probiotic bacterium, called Bacillus subtilis, was found to be significantly effective in not only inhibiting alpha-synuclein aggregation but also reversing pre-formed accumulations [in a laboratory worm model]. Much more at: https://newatlas.com/medical/gut-bacteria-mic...event-parkinsons-disease/ Thank you very much for a very interesting link! ![]() Join The International Team: https://www.worldcommunitygrid.org/team/viewTeamInfo.do?teamId=CK9RP1BKX1 AMD TR2990WX @ PBO, 64GB Quad 3200MHz 14-17-17-17-1T, RX6900XT @ Stock AMD 3800X @ PBO AMD 2700X @ 4GHz |
||
|
l_mckeon
Senior Cruncher Joined: Oct 20, 2007 Post Count: 439 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Prediabetes associated with bacterial shifts in the gut microbiome
Researchers from the University of Gothenburg have for the first time studied the gut microbiome of subjects with prediabetes. The study, published in the journal Cell Metabolism, reveals a person’s unique gut bacteria population could be used to predict their likelihood of developing type 2 diabetes. The new study arose out of the observation that, while some research has previously investigated the link between the gut microbiome and diabetes, most of those studies consisted of comparing healthy individuals with those already diagnosed with the condition. [. . .] Further research is needed to understand whether microbiome changes (potentially influenced by diet) are directly causing the subsequent metabolic problems, or whether the microbiome is simply responding to the metabolic disease. Much more at: https://newatlas.com/health-wellbeing/prediab...-bacteria-gut-microbiome/ |
||
|
l_mckeon
Senior Cruncher Joined: Oct 20, 2007 Post Count: 439 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Swallowable capsule(s) gather bacteria from the gut
----------------------------------------Two different laboratories have invented ingestible capsules for obtaining microbiome samples from specific regions of the G.I. tract, as opposed to fecal sampling which has everything mixed together. https://newatlas.com/medical/swallowable-capsule-gut-bacteria/ https://newatlas.com/gut-bacteria-sampling-capsule/60762/ [Edit 2 times, last edit by l_mckeon at Aug 15, 2020 1:28:17 AM] |
||
|
Jim Slade
Veteran Cruncher Joined: Apr 27, 2007 Post Count: 665 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
The Human Microbiome and its Links to Communicable and Non-Communicable Diseases
CDC Webinar, November 5, 2020, 11:00am-12:00pm ET In this webinar, Dr. Rob Knight of UCSD will give discuss emerging opportunities and examples for using the microbiome to improve health and prevent disease at the individual and population levels. Our discussant CDC's Dr. Clifford McDonald will give an overview of several CDC initiatives in microbiome and public health research and program implementation. https://www.cdc.gov/genomics/events/microbiome_2020.htm ![]() |
||
|
[VENETO] boboviz
Senior Cruncher Joined: Aug 17, 2008 Post Count: 183 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Microbiome and tumors
Bacteria were first detected in human tumors more than 100 years ago, but the characterization of the tumor microbiome has remained challenging because of its low biomass. We undertook a comprehensive analysis of the tumor microbiome, studying 1526 tumors and their adjacent normal tissues across seven cancer types, including breast, lung, ovary, pancreas, melanoma, bone, and brain tumors. We found that each tumor type has a distinct microbiome composition and that breast cancer has a particularly rich and diverse microbiome. The human tumor microbiome |
||
|
l_mckeon
Senior Cruncher Joined: Oct 20, 2007 Post Count: 439 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
New evidence links age-related cognitive decline & the gut microbiome
Scientists from the UK and Italy have found fecal transplants from old mice to young mice result in the younger animals displaying learning and memory impairments. The findings build on a growing body of research linking age-related cognitive decline with gut microbiome changes. [. . .] However, the causal relationship between the microbiome and the brain is still deeply unclear. We do know that changes in the brain can influence changes in the microbiome. Experiments inducing strokes in mice, for example, were found to subsequently alter bacterial populations in the gut. On the other hand, we've also seen metabolites produced by gut bacteria traveling up into the brain and exacerbating neurovascular disease. So it seems increasingly clear the gut-brain axis is both incredibly complex and deeply bi-directional. Much more at: https://newatlas.com/science/cognitive-declin...a-mouse-study-microbiome/ |
||
|
Jim Slade
Veteran Cruncher Joined: Apr 27, 2007 Post Count: 665 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
Microbes and microbiomes in 2020 and beyond | Nature Communications
In the next decade, advances in our understanding of microbes and microbiomes will likely transform our way of life; providing novel therapeutics, alternate energy sources, and shaping fundamental doctrines of biology. We explore the promises herein and tools required to achieve the progress. https://www.nature.com/articles/s41467-020-18850-6 ![]() |
||
|
|
![]() |