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World Community Grid Forums
Category: Active Research
Forum: OpenPandemics - COVID-19 Project
Thread: Questions about the science behind OPN project? |
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Thread Status: Active Total posts in this thread: 11
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chiara.p
World Community Grid Admin, Mapping Cancer Markers Scientist Joined: Jul 15, 2020 Post Count: 28 Status: Offline |
Dear volunteers,
during the two months of shutdown we would like to take the time to answer to some of the questions you might have about the projects (and never thought to ask  ). We will collect all you write in the forum in the next few days and, with the collaboration of all the active projects groups, try to answer as many questions as possible. If they are going to be too many, we will prioritize them by the number of people that “+1” them. What we will not be able to answer during the final phase of the migration, will be answered later on. |
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Sgt.Joe
Ace Cruncher USA Joined: Jul 4, 2006 Post Count: 7687 Status: Offline Project Badges: 
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Is there any collaboration between the OPN project here and the Folding @ Home Pandemic project ?
----------------------------------------Cheers
Sgt. Joe
*Minnesota Crunchers* |
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bikeaddict
Cruncher Joined: Apr 11, 2020 Post Count: 32 Status: Offline Project Badges: 
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For all projects, I'd like an overview of the team and what they do, including:
- Area of expertise, role and responsibilities of each team member - The computer hardware, OS, software and programming languages used - Details about how the process of generating and distributing tasks, and validating and analyzing results works - How the process of deciding on new projects works - How a project comes to a conclusion - What usually happens with the results of a concluded project |
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Dayle Diamond
Senior Cruncher Joined: Jan 31, 2013 Post Count: 452 Status: Offline Project Badges: 
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Is there any progress on getting the GPU app to minimize hard disk usage?
Since the project is going to be offline for so long, is it possible to offset some of these losses by converting several months of would-be CPU work into a rush of GPU work upon resumption? Presumably the scientists will have plenty of time to prepare them. |
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Jim1348
Veteran Cruncher USA Joined: Jul 13, 2009 Post Count: 1066 Status: Offline Project Badges: 
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(1) How do you choose the best candidates for the next step? Is it merely the tightest bond, or do you have other criteria?
(2) Can you make any estimates on possible side effects, the Achilles heel of most drug design projects I believe. Does the size of the molecule play a role in that, for example. (3) How much of the subsequent testing is done in-house at Scripps, and at what point do you send it out? (4) Any estimates on the time frames? |
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stopcancer
Cruncher Joined: Dec 10, 2013 Post Count: 6 Status: Offline Project Badges:
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Which pharmaceutical companies are using this research?
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Rickjb
Veteran Cruncher Australia Joined: Sep 17, 2006 Post Count: 666 Status: Offline Project Badges:
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On 8 Jul 2021, in the WCG News article Approximately 300 million small molecules run...19 as part of system test , it was mentioned that the 75 of those molecules that looked most promising for binding to the SARS-CoV2 proteases Plpro and Mpro had been synthesised and shipped to collaborating labs for testing.
----------------------------------------The article then says "as soon as biological results are available, we will share them with the community." Well, I'm still holding my breath for those results and am getting - um - just a bit blue in the face ... [Edit 1 times, last edit by Rickjb at Jun 29, 2022 1:12:51 PM] |
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Grumpy Swede
Master Cruncher Svíþjóð Joined: Apr 10, 2020 Post Count: 2195 Status: Offline Project Badges:
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Again, Patience. It can take years for such lab results to be finished, and ready to be released. This is not a sprint race, it's an Ultra-marathon.
----------------------------------------[Edit 2 times, last edit by Grumpy Swede at Jun 29, 2022 9:42:43 AM] |
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biscotto
Cruncher Italy Joined: Apr 11, 2020 Post Count: 27 Status: Offline Project Badges: 
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It's been almost four months, why no answers from the team?
----------------------------------------I would also like to ask:
Thanks in advance! Papa Ryzen 5 3600 / Mama Radeon RX 560 |
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Falconet
Master Cruncher Portugal Joined: Mar 9, 2009 Post Count: 3295 Status: Offline Project Badges: 
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It's been almost four months, why no answers from the team? I would also like to ask:
Thanks in advance! The data generated by WCG has to be published and available for anyone who wants it. That's part of the agreement that projects and WCG sign. AutoDock is already open source software and that includes the GPU version. AMD Ryzen 5 1600AF 6C/12T 3.2 GHz - 85W AMD Ryzen 5 2500U 4C/8T 2.0 GHz - 28W AMD Ryzen 7 7730U 8C/16T 3.0 GHz |
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