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World Community Grid Forums
Category: Official Messages
Forum: News
Thread: Research update from the MCM team (May 2024) |
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Thread Status: Active Total posts in this thread: 5
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WCGAdmin
World Community Grid Admin Joined: Jun 9, 2020 Post Count: 171 Status: Offline |
We continue to characterise lung cancer biomarkers identified in the MCM1 project. This update focuses on KLF5, a well-studied gene that has been implicated in several cancer types. KLF5 is a transcription factor, which is expressed across numerous organs and tissues.
https://www.worldcommunitygrid.org/about_us/article.s?articleId=812 |
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alged
Master Cruncher FRANCE Joined: Jun 12, 2009 Post Count: 2358 Status: Offline Project Badges: 
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THKS for that report we crunch more and more !!
---------------------------------------- NOUS SOMMES TOUS DES CHERCHEURS EN PUISSANCE  |
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kefeiwu
Cruncher Joined: Mar 13, 2018 Post Count: 1 Status: Offline Project Badges: 
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Hello MCM team!
First thank you for putting out those nice articles, it is very exciting to hear new development from you. However I have a layman question, the article looks like statistics of a gene wrt survival rate. And I was wondering what effects of the calculations plays in those findings. May be I have missed some of your article but I couldn't find it. I've read the CONCORD article and it didn't give calculation details either. Or perhaps at this amount of data is so big, doing the statistic itself is the calculation we're running? Cheers Kefei Wu |
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TigerLily
Senior Cruncher Joined: May 26, 2023 Post Count: 280 Status: Offline Project Badges: 
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Hi kefeiwu,
Thanks for your question! The MCM project focuses on analyzing large datasets to identify diagnostic, prognostic, and predictive signatures. The MCM project, and the calculations volunteers complete, do not contribute to calculating survival rates. We just provide survival curves in our updates to offer some additional context about each gene's relevance to lung cancer. The survival curves included in this update were taken from Kaplan-Meier plotter. More details about the survival analysis can be found in this article by Gyorffy B: https://doi.org/10.1111/bph.16257. Let me know if you have any other questions about this and I'm happy to provide further clarification! |
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Jeff Wade
Cruncher USA Joined: Jun 1, 2005 Post Count: 25 Status: Offline Project Badges: 
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Hello,
----------------------------------------Thank you for that update. Could you please provide a characterization of the status of work regarding sarcoma? Thank you. [Edit 1 times, last edit by Jeff Wade at Jun 4, 2024 2:43:36 PM] |
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