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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
I have a question about how the knowledge that we create will be turned into drugs and provided to people.
On the one hand, I think it is great that all of the information that we create is going to be kept in the public domain, so that it can be widely used to help find better treatments for AIDS. On the other hand, I wonder who will go about putting in the extra investment necessary to test our ideas, including all of the necessary clinical trials and applications for drug approval, and manufacture the drugs, if everything stays in the public domain. I was fairly clear about this situation on the human proteome project, but that seemed to be more fundamental research, whereas FightAIDS@home seems to be much closer to product development. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Hello Christine MH,
So far the most detailed information that we have is included in the MedLinePlus story you found: Olson said the project's first phase will test about 2,000 compounds representing a much larger set of similar chemicals against about 200 mutant variations of the HIV protein If you look at the AutoDock site ( http://www.scripps.edu/mb/olson/doc/autodock/ ) at Scripps ( http://www.scripps.edu/mb/olson/ ) you will see that AutoDock 4.0 is really new. It will take some time to determine how well it is working. So when will TSRI release information about results and what groups will see it first? I don't know. Ultimately it will all be publicly available for any researcher to look at. But note that Dr. Olson is just calling this phase 1, as they look at a representative sample from a number of different groups of compounds. And by contract, all the results we create on the World Community Grid are public domain and must be maintained in a database that is publicly accessible in a reasonable length of time (usually no later than publication of the research paper). mycrofth |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
On the other hand, I wonder who will go about putting in the extra investment necessary to test our ideas, including all of the necessary clinical trials and applications for drug approval, and manufacture the drugs, if everything stays in the public domain. Private labs, of course "What used to take months can now be done in weeks." (GlaxoSmithKline). This data will be the "point of start" for those trying to develop some working drugs. They will make the investment and take the profits. And by contract, all the results we create on the World Community Grid are public domain and must be maintained in a database that is publicly accessible in a reasonable length of time (usually no later than publication of the research paper). . Lets see how this contract face the laboratories desire to keept their developments protected by patents. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Anything that they develop is theirs, true enough. We are releasing what we do to the world, to serve as a starting point.
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Thank you for your replies. I was wondering because it seems to me that this issue is one that needs to be managed very carefully.
Personally, as a cancer patient on a very expensive treatment, I am ambivalent about the drugs companies. The treatment I am on, a monoclonal antibody) is very likely to make a huge difference to my chances for survival, despite being much less debilitating than the other treatments I have had, so I understand what it is like to have one's life depend on drug innovations. I know people hate the drugs companies, but sometimes the drugs really make a difference and, having had my immune system temporarily devastated by chemo lots of times, I know that I would hate to have AIDS. On the other hand, my treatment is so expensive that many people who need it can't afford it, even in the United Kingdom, which is, in the grand scheme of things, a relatively prosperous country. I can just about afford it myself and health care systems everywhere are really struggling with the cost of this drug, so I can understand why people aren't happy about drug company prices and problems of availability. Personally, I try to console myself with the thought that even if the drugs companies develop something from our public domain intellectual property that they can patent, patents don't last forever and the sooner things get on patent, the sooner they will come off. If we accelerate the search for AIDS drugs like we have speeded up folding of the Human Proteome, I would hope that we would save more than the fifteen years covered any patent would cover. |
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Ben Pont
Cruncher Joined: Nov 24, 2004 Post Count: 4 Status: Offline |
On the other hand, I wonder who will go about putting in the extra investment necessary to test our ideas, including all of the necessary clinical trials and applications for drug approval, and manufacture the drugs, if everything stays in the public domain. Private labs, of course "What used to take months can now be done in weeks." (GlaxoSmithKline). This data will be the "point of start" for those trying to develop some working drugs. They will make the investment and take the profits. I don't mind private industry taking profits, so long as a low cost "generic", but equally effective alternative can be furnished to the poorer population that can't afford "name brand" drugs. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
It is obviously the large drug companies who are going to make use of the results of this work, and I have no problem with this so long as the final price of the drug reflects the fact that a significant aount of the research work was done for them.
However what is at the back of my mind any probably many other is that companies will attempt to hijack the work mach as they did with the human genome project where chunks of human DNA were patented for particular treatment applications, thus effectively blocking others for developing gene therapies based on that gene sequence. Hopefully someone has thought of this and the the result will be protected is some way thus preventing companies from patenting the various molecules and dockings we all busy analysis. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Hello Hanmere,
We are providing "prior art" by placing our results in the public domain. Just what effect this has in a patent infringement action between competing claims is up to the lawyers and the judges. |
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TheSwampDweller
Cruncher Joined: Nov 21, 2005 Post Count: 4 Status: Offline |
Hello Hanmere, We are providing "prior art" by placing our results in the public domain. Just what effect this has in a patent infringement action between competing claims is up to the lawyers and the judges. It's good to hear this. ![]() ![]() ![]() |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
The most you can hope for is the results of this compute will be put in a user friendly type database and the results of what did and did not work become available to whoever has the capability of doing something with them.
What I hope does not happen is what oxford university did with the Think and ligand fit computes on grid.org which was to put all results in a black hole and no body seems to know what became of 4-5 years of computing effort by millions of people. Because of this lack of comunication problem by most labs involved in actual drug discovery. I personaly have some personal misgivings as to any drug developement compute. Mainly for the reason these labs fail to say anything at all but use millions of computers to run thier agents. I am very impressed with the ISB peoples HPF project run on world community grid. And the University of Washington Baker Lab rosetea effort. For communicating any and all results and goals. I hope Scripps follows through and keeps us informed as to progress results and future plans. ciao!!! |
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