| Index | Recent Threads | Unanswered Threads | Who's Active | Guidelines | Search |
 |
World Community Grid Forums
Category: Completed Research
Forum: Human Proteome Folding
Thread: Is there any result in treatment or we just resolve more and more proteins? |
| No member browsing this thread |
|
Thread Status: Active Total posts in this thread: 7
|
|
| Author |
|
|
Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
The topic is the question
|
||
|
|
Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Hello Don Trzaska,
The Human Proteome Folding project is basic medical research. We are given some fundamental components of cells (proteins of unknown function) and we try to deduce their shape, then from this deduce which other proteins they interact with, and how. It is like pouring the components of an Erector set onto the living room floor and trying to figure out what goes with what. The goal is to figure out the functional networks that drive basic cell processes. Once you have identified the function of a protein you can: 1) Select it as a target for a drug to interfere with its function. 2) Figure out how it works and design a drug to duplicate the effect. 3) Develop a diagnostic test to detect the concentration of that protein in order to measure the level of activity. Without the protein information, these three things are very important objectives that can only be accomplished by mass screening of a vast number of chemical compounds, hoping for a lucky breakthrough. Even with this information, a great deal of work, skill and luck is required to develop a drug. The HPF project can provide very useful information for drug development, but it is aimed at basic understanding that can then be used to develop drugs. We are providing the shape information. Scientists studying the databases with this structural information will predict the function of the proteins (annotate the proteins). mycrofth |
||
|
|
Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Hi,
Will we be informed once there's a drug based on the HPF (or FAAH) research? Itay |
||
|
|
Viktors
Former World Community Grid Tech Joined: Sep 20, 2004 Post Count: 653 Status: Offline Project Badges: 
|
Hi, Will we be informed once there's a drug based on the HPF (or FAAH) research? Itay When something major is produced, I am fairly certain we will have some information posted about that here. Keep in mind, however, that it takes years of work to develop and test a drug. The research computations we crunch here are going to help many researchers with steps in their projects. Some may only mention that the information computed here was used as a reference and it will be up to them to explain how helpful or essential it was for their particular project and give us appropriate credit. |
||
|
|
Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
thank you very much for the big reply. But what I wanted to know was just if someone had used this project results and had made anything out of them yet? For example, as you wrote:
1) Select it as a target for a drug to interfere with its function. 2) Figure out how it works and design a drug to duplicate the effect. 3) Develop a diagnostic test to detect the concentration of that protein in order to measure the level of activity. I wonder if you have information, that someone used it the way you write, but it seems you haven't. I'm proud i attend to the project and I will. I was just wondering. Have a nice day |
||
|
|
Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Hello Don Trzaska,
Here is the latest report from Dr. Bonneau: http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=5279 Some scientists have been annotating proteins since the beta of the database went online in September, but we shall have to wait to see how the annotation goes. And then there will probably be a long wait before any citations to these annotations start showing up.  mycrofth |
||
|
|
RicktheBrick
Senior Cruncher Joined: Sep 23, 2005 Post Count: 206 Status: Offline Project Badges: 
|
Here is an interesting article http://blogs.zdnet.com/emergingtech/?p=120. I just hope that our effort have contributed to this database of proteins.
|
||
|
|
|