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Category: Completed Research
Forum: FightAIDS@Home
Thread: Interesting news articles about AIDS |
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Thread Status: Active Total posts in this thread: 1122
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Papa3
Senior Cruncher Joined: Apr 23, 2006 Post Count: 360 Status: Offline Project Badges: 
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Scientists make cells RESISTANT to HIV in major breakthrough against the disease
----------------------------------------The research, conducted at The Scripps Research Institute (TSRI) in San Diego, California, first tested their system against rhinovirus, which is responsible for many cases of the common cold. They used a vector called lentivirus to deliver a new gene to cultured human cells. The team then had cells synthesize antibodies that bind with the human cell receptor that rhinovirus needs to gain access. With the antibodies monopolizing that site, the virus cannot enter the cell to spread infection. Cells without antibody protection died off, leaving protected cells to survive and multiply, passing on the protective gene to new cells. In the technique tested against HIV, all strains of the virus need to bind with a cell surface receptor called CD4. After introducing cells to the virus, the researchers ended up with an HIV-resistant population. The antibodies recognized the CD4 binding site, blocking HIV from getting to the receptor. 'This is really a form of cellular vaccination,' said senior author Dr Richard Lerner, Professor of Immunochemistry at TSRI. http://www.dailymail.co.uk/health/article-440...-cells-RESISTANT-HIV.html https://www.sciencedaily.com/releases/2017/04/170410154718.htm [Edit 1 times, last edit by Papa3 at Apr 12, 2017 6:29:21 AM] |
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Jim Slade
Veteran Cruncher Joined: Apr 27, 2007 Post Count: 664 Status: Offline Project Badges: 
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NIMH: New Source of HIV Persistence Identified
Scientists have shown that a class of immune cells not thought to be a primary reservoir of HIV can harbor the virus even following antiretroviral (ART). The persistence of HIV in this type of cell - macrophages- means that treatment to eradicate HIV will have to target these cells in addition to those already demonstrated to have a role in the rebounding of HIV if ART is stopped. https://www.nimh.nih.gov/news/science-news/20...sistence-identified.shtml  |
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Jim Slade
Veteran Cruncher Joined: Apr 27, 2007 Post Count: 664 Status: Offline Project Badges:
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No link found between HIV levels and immune activation during antiretroviral treatment
Despite successful treatment, people receiving antiretroviral drugs continue to have small amounts of human immunodeficiency virus (HIV) in their blood, as well as elevated immune system activation. However, new research shows no correlation between those two measurements. https://www.sciencedaily.com/releases/2017/04/170420141908.htm |
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Jim Slade
Veteran Cruncher Joined: Apr 27, 2007 Post Count: 664 Status: Offline Project Badges:
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Dr. Anthony Fauci Explains New HIV Research Findings in NIAID Video
Watch Dr. Anthony Fauci describe how the presence of a protein newly identified on HIV called alpha-4 beta 7 integrin may help explain how an antibody treatment led to sustained remission of an HIV-like virus in monkeys. The new findings from Dr. Fauci's lab were published today in the journal Science Immunology. https://www.youtube.com/watch?v=nQh9knbmtwo |
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Papa3
Senior Cruncher Joined: Apr 23, 2006 Post Count: 360 Status: Offline Project Badges:
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CRISPR kills HIV and eats Zika 'like Pac-Man'. Its next target? Cancer.
http://www.wired.co.uk/article/crispr-disease-rna-hiv |
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Jim Slade
Veteran Cruncher Joined: Apr 27, 2007 Post Count: 664 Status: Offline Project Badges:
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36 years and counting: AIDS in America
Though modern medicine has done much to control the disease since it first caught the attention of public health officials, the battle against HIV is far from over. This is a CBS news special report. http://www.cbsnews.com/news/36-years-and-counting-aids-in-america/ |
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Jim Slade
Veteran Cruncher Joined: Apr 27, 2007 Post Count: 664 Status: Offline Project Badges:
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'Trump doesn't care about HIV. We quit' 6 experts submit resignation letter to US HIV/AIDS Council
Six experts have resigned from the Presidential Advisory Council on HIV/AIDS (PACHA) https://www.rawstory.com/2017/06/trump-doesnt...er-to-us-hivaids-council/ |
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Papa3
Senior Cruncher Joined: Apr 23, 2006 Post Count: 360 Status: Offline Project Badges:
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Figuring out the 3-D shape of molecules with a push of a button - A team of researchers has developed a program that automates the process of figuring out a molecule's three-dimensional structure. The technique compresses a process that usually takes days into minutes and could shorten the pipeline of drug discovery by reducing human error.
https://www.sciencedaily.com/releases/2017/06/170619125831.htm |
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Papa3
Senior Cruncher Joined: Apr 23, 2006 Post Count: 360 Status: Offline Project Badges:
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New computational method learns how to estimate bond energies as well as a trained synthetic chemist
Parkhill and his team created a piece of software that breaks down molecules, then analyses and classifies single bonds according to their different electronic properties. Next, chemists taught the neural network using an existing database of over 130,000 molecules.2 With this information, and combining it with a series of different algorithms, the programme is able to predict bond energies, often beating the intuition of trained synthetic chemists. (Image: On the left, a scheme of how the neural network is trained up by feeding it information on the bond energies of a range of molecules. On the right, the network’s predictions of the bond energies of morphine) Alan Aspuru-Guzik, a theoretical chemist at Harvard University, US, believes ‘the paper by Parkhill is very exciting from several angles’. He explains how ‘their representation can be readily extended and combined with other approaches […] to generate novel molecular structures in design applications – something that interests many of us in the community’. The accuracy of this new method amazes Aspuru-Guzik. ‘Chemical accuracy is the gold standard of quantum chemistry. [What] Parkhill and co-workers reached is fabulous.’ Neural networks are useful tools, even comparable to human intuition, but Parkhill and Aspuru-Guzik agree they cannot replace trained chemists. ‘Chemists [can] make rational choices about molecular structures in the same way a chess grandmaster makes decisions about chess. An artificial intelligence system may predict better energies or geometries, but may not be able to make decisions,’ says Aspuru-Guzik. ‘[Our network] predicts [data] quantitatively and reproducibly. It saves chemists from the impossible tedium of predicting an energy a billion times,’ explains Parkhill. https://www.chemistryworld.com/news/neural-ne...ike-a-pro/3007598.article |
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Papa3
Senior Cruncher Joined: Apr 23, 2006 Post Count: 360 Status: Offline Project Badges:
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http://www.futurity.org/libraries-of-cloned-genes-1470402/
To [quickly] find new drugs, [start by rapidly generating molecule] ‘libraries’ from DNA A new technology can clone thousands of genes at once and compile libraries of proteins from DNA samples, potentially speeding up the search for new drugs. Discovering the function of a gene requires cloning a DNA sequence and expressing it. Until now, this was performed on a one-gene-at-a-time basis, causing a bottleneck. ... In a study published in the journal Nature Biomedical Engineering, the researchers show that their technology—LASSO (long-adapter single-strand oligonucleotide) probes—can capture and clone thousands of long DNA fragments at once. As a proof-of-concept, the researchers cloned more than 3,000 DNA fragments from E. coli bacteria, commonly used as a model organism with a catalogued genome sequence available. ... They can now take a genome sequence (or many of them) and make a protein library for screening with unprecedented speed, cost-effectiveness, and precision, allowing rapid discovery of potentially beneficial biomolecules from a genome. ... The team also reported the capture and cloning of the first protein library, or suite of proteins, from a human microbiome sample. ... Today, the pharmaceutical industry screens synthetic chemical libraries of thousands of molecules to find one that may have a medicinal effect, says Parekkadan. “Our vision is to apply the same approach but rapidly screen non-synthetic, biological, or ‘natural’ molecules cloned from human or other genomes, including those of plants, animals, and microbes,” he says. “This could transform pharmaceutical drug discovery into biopharmaceutical drug discovery with[out] much more effort.” ... The next phase, which is underway, is to improve the cloning process, build libraries, and discover therapeutic proteins found in our genomes ... Additional authors are from Harvard Medical School; the University of Trento in Trento, Italy; and Johns Hopkins University. Source: Rutgers University http://news.rutgers.edu/research-news/cloning...ies/20170621#.WVJ3-hPyv-a Original Study DOI: 10.1038/s41551-017-0092 https://doi.org/10.1038/s41551-017-0092 |
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