Index  | Recent Threads  | Unanswered Threads  | Who's Active  | Guidelines  | Search
 

Quick Go ยป
No member browsing this thread
Thread Status: Active
Total posts in this thread: 3
[ Jump to Last Post ]
Post new Thread
Author
Previous Thread This topic has been viewed 1485 times and has 2 replies Next Thread
Former Member
Cruncher
Joined: May 22, 2018
Post Count: 0
Status: Offline
Reply to this Post  Reply with Quote 
Reply from another message board...

i posted about wcg and this guy replied as follows:

"you don't need a computer grid for that, you need a crystallographer like me to solve the structures of the relevant targets and to bind in some rule of 5 inhibitors so you can go right to the rat-killing stage and eventually into the clinic. Tell you what, you give me the cash, I'll give you the structure of telomerase and then 1,000+ people a day don't have to die of cancer."

does this make any sense?
[Feb 22, 2006 10:43:48 PM]   Link   Report threatening or abusive post: please login first  Go to top 
Former Member
Cruncher
Joined: May 22, 2018
Post Count: 0
Status: Offline
Reply to this Post  Reply with Quote 
Re: Reply from another message board...

It makes sense, with caveats. There are a number of different ways to proceed. Our computational method is fairly new but there are already a number of similar programs, and the number is growing. There is no one path to the future.
[Feb 23, 2006 2:40:05 AM]   Link   Report threatening or abusive post: please login first  Go to top 
Former Member
Cruncher
Joined: May 22, 2018
Post Count: 0
Status: Offline
Reply to this Post  Reply with Quote 
Re: Reply from another message board...

he's making it seem far simpler than it actually is. For all of that research to fully go through, you'd probably need at least several months for EACH protein. there's obviously not enough manpower to do that with the whole genome. Not just that, "several months" is an estimate for probably a very easy-to-analyze protein. There are plenty of protein structures which have stumped scientists and started debates between scientists with different models for years and have evaded crystallography methods. Currently, scientists usually only look at proteins which seem interesting or which seem to be involved in cancer or aids or such. Projects like WCG can give a rough estimate of the shape of proteins so that scientists can tell which proteins are good candidates for further experimentation.

Not just that, I'm quite certain cancer isn't so simple as just telomerase. Assuming you can even can find a safe inhibitor of telomerase, you'd also be inhibiting all the stem cells in your body (i.e. hair falls out, nails don't grow anymore, low blood cell counts). It'd also take at least a while for the cancer cells to die, because you'll probably need something like 20+ cell divisions before the telomeres finally degrade. And then you'll be stuck with a whole bunch of dead stem cells.

Bottom line, he wants your $$$$!!!
[Mar 6, 2006 5:01:54 AM]   Link   Report threatening or abusive post: please login first  Go to top 
[ Jump to Last Post ]
Post new Thread