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Former Member
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What is the progress so far?

Out of the 9 million combination that we need to test, how many have been tested already?
Is there a specific order for the combination? Do the scientists 'suspect' that one of the three proteins is more likely to find matches in a specific group of the 3 million drugs and therefore we started to experiment by testing those?

Is there a plan of action after a certain number of tests have been done? Like checking the first 5000 tests and see how those drugs bind. In case the binding of certain drugs is completely poor, is there a way to anticipate that similar drugs will have a poor result as well and therefore those won't be tested?

Thanks for any answers.

Regards,

Lucas Wall
Virginia, USA
Two computers working, and networking with as many family members, and friends to make them join.
Father of Santi, 8 years old, NB Stage IV (www.caringbridge.com/visit/santi)
[Mar 23, 2009 2:07:28 AM]   Link   Report threatening or abusive post: please login first  Go to top 
Former Member
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Re: What is the progress so far?

It is a little early for the scientists to begin updating us about progress, but I believe the first batches of results have already been completed and returned to the researchers.

Even small differences in molecules can have a big impact on their effectiveness, so, while there are ways to optimise the search, it isn't as simple as eliminating similar compounds. I'm not sure what compounds the researchers are testing, but usually they will run a "diversity set" of very dissimilar compounds first. This lets them cover the most ground early on.

Remember that even if a lead were to be found tomorrow, it still takes years of testing before a drug is approved. Don't lose hope, though - other researchers will have other drugs already in the testing phase. A breakthrough may come at any time.
[Mar 23, 2009 2:20:24 AM]   Link   Report threatening or abusive post: please login first  Go to top 
Col323
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Re: What is the progress so far?

Out of the 9 million combination that we need to test, how many have been tested already?

I'll piggyback this topic with a question of my own. There are 9 Million tests to run. Ideally, does that correspond to 9 Million results which must be returned for this project? If so, how can the techs slice work into the 7 hr average work units? Let's say they wanted to slice them into 3.5 hr average work units. Would that mean we now have 18 Million results to return?

Also, let's say that with a Quorum of One, it is 9 Million results to return for the 9 Million tests the project requires. The latest stats say we have returned 322,304 results. Would that number include any Quorum of Two results - ie, when all is said and done, will we have maybe 9.2 Million results for the 9 Million tests? Is there any way to tell what percentage of the Results Returned figure includes work beyond the Quorum of One?
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Sekerob
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Re: What is the progress so far?

Unless we get work intermittent as we have with CEP, 40000 tasks a day, presently, and still warming up with a project length of 2 years gives a cool 29,200,000 results, which would include the double checks, but our stats do only show valid results.

The work in the batches is sliced differently than the 9 million suggest. As you will have surmised from other WCG projects, this can be done at will except for HCC which are unique and unsplittable single target image analysis. Given there is a library of a few million compounds to be tested against 3 or more specific targets requiring each a variable number of docking attempts to find the best fit, the tests can be compiled so they each run with a target project mean of 7 hours.

If the project produces too much data too fast, we could be facing RICE and DDDT situations... an intentional slow down, so with all this, not sure how many tasks there will or how many CPU years, which I think were initially estimated to be 8,000, which at present 20.2 7 day mean fills 400 days work.

Good thing this is Zero Redundancy and not Quorum 2 ;-)

Added: If this 8,000 CPU years was extrapolated from tests on a P3, this project could finish sooner than later :D
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[Edit 4 times, last edit by Sekerob at Mar 24, 2009 3:17:20 PM]
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Col323
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Re: What is the progress so far?

Thanks for that detailed explanation! That really helps my understanding of HFCC and WCG in general. Plus, I'm a stats head and enjoy looking at numbers in many different ways. Even though I really enjoy your graphs, I still keep my own spreadsheets and try to calculate progress, end dates, etc for fun. It's entertaining to compare my numbers to yours and see how close or how terribly far off I am. smile Most of all, I really like the feeling of making progress in a project, and I try to follow that as best as I can. I like to track how far along we are, when we might finish, and how an influx of power might shorten the enddates. biggrin
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Re: What is the progress so far?

Hi Col323,

Would you mind sharing your calculations/spreadsheet? I am having a hard time understanding the statistics available through the same named module in the GCD application. confused

I am trying to see simple things, like estimated date for completion under current speed, number of scripts already calculated and to be calculated.

I really don't understand what those measures in the stats module mean, it says User Total 1400, what is that? Hours? Certainly not hours. User average 150, what about this one? The charts have no legend of the variable being reported. sad

Any explanation would mean a lot because I am gathering more data to explain to others. smile

Thanks!
[Mar 26, 2009 3:04:59 AM]   Link   Report threatening or abusive post: please login first  Go to top 
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Re: What is the progress so far?

In the FAQ section you can also find some statistics WCG wide maintained by Sekerob:
http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=18277
[Mar 26, 2009 8:29:13 AM]   Link   Report threatening or abusive post: please login first  Go to top 
Col323
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Re: What is the progress so far?

Hi lwall_mba,

I'll second what Harreld said. Sekerob does some great analysis, plus he knows how things work behind the scenes. My numbers aren't meant for public consumption and I would wager are far less accurate than his.

If you have specific questions, don't hesitate to post. People here are quite willing to help. Developing a better understanding of WCG keeps us all motivated, and is very helpful when recruiting others.

Cheers!

Col323
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Sekerob
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Re: What is the progress so far?

Each project forum has a Crunching aka Performance Chart thread as does this project:

http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=24775

It's usually very close to the bottom of the forum thread list.
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[Mar 26, 2009 1:31:06 PM]   Link   Report threatening or abusive post: please login first  Go to top 
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Re: What is the progress so far?

I know I saw a bunch of new recruits for the CEP project but hadn't really noticed if there were a lot of new crunchers being drawn in for this project. Do we know if there was a big jump in registrations around the time the press release went out for this project?
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