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Flood of Human Genome Data Coming, How Do We Make the Most of It ?

Recently, while listening to a radio program predicting that within a few years we all might be able to have our genome's sequenced for much less than $1,000, it occurred to me how much medical data could be gleaned from comparing the resulting genome data with a well designed medical questionnaire.

The end result might produce new clues as to what genetic patterns are related to which medical conditions and diseases. In a macro way, the organized data from thousands or millions of human genomes could point researchers in new directions that they could then examine more closely.

Anonymous data and questionnaire results could be collected from the companies or organizations doing the genome sequencing, and people having their genome sequenced would only have to sign a form allowing their raw data to be passed along without names or any identification attached.

It seems the World Community Grid might be a perfect place to quickly crunch the data and build an open source data base that could be easily accessed by genetic researchers across the globe.

No doubt, some of the sequencing companies may want to withhold data, do their own deeper analysis and sell it to researchers, but if this macro data was organized on a grand not-for-profit scale the resulting information might have the greatest impact for human health in the shortest period of time. The sequencing companies would still be able to analyze their data in a more targeted way, but the big macro picture could be totally open source.

I am just a layman in this area, but with the rate of decline in the cost of genome sequencing accelerating thanks to new technology, now might be the time researchers should be thinking about designing a proper questionnaire, and writing the software needed to crunch all the data that will suddenly result from the cost drop.

When the cost of sequencing comes down around the cost of an annual physical, the flood of new genetic data could suddenly be overwhelming.

Again, I am just a layman and for all I know some government agency or international NGO already has big plans to do this, but I thought I might throw the idea out there just in case. The quickest and greatest benefits would undoubtedly come from a totally open source plan. We know the flood of potentially useful data is coming, the question now is: What will we do with all that potential when it suddenly arrives?
[Jan 1, 2011 9:54:44 PM]   Link   Report threatening or abusive post: please login first  Go to top 
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Re: Flood of Human Genome Data Coming, How Do We Make the Most of It ?

Hi CaptainMidnight,

I recently read an article that said that the giddy predictions made before 2000 about the immediate utility of genomic data had almost completely failed. It will take a lot of scientific thought and research to turn that data into useful information.

biggrin Of course, that is just what I thought back in the 90's. It just means a lot of perspiration needs to be shed in order to gain the inspiration that will lead to useful and usable advances. We are contributing a little of that perspiration. A lot more is being given by the scientists working with all this data.

tongue
Good luck and best wishes to all in 2011 and in coming years!
Lawrence
[Jan 2, 2011 2:03:09 AM]   Link   Report threatening or abusive post: please login first  Go to top 
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Re: Flood of Human Genome Data Coming, How Do We Make the Most of It ?

The human genome project was a catastrophic demonstration of overinvestment in one scientific area at the expense of all others. Not only did progress slow in many fields of science but many skill sets depleted. The reality of scientific research is that it often takes several generations of scientists working on the same problems to come up with major breakthroughs. Some research fields were lost entirely and many fields with great potential to make scientific and health breakthroughs were denied the opportunity to progress. Of course these are now the very skill sets required to utilise the raw data of the HGP. In science whoever shouts the loudest get heard, and the rest get shouted down. At the minute there is still overinvestment in the HGP and a lack of investment in other fields - the fields that can actually make use of this data.
A parallel to this is the Climate Change bandwagon. You would think that Carbon was the only chemical emission. Well, it's not. There are 18Million manmade chemicals leaking into the environment and populations, but only one gets mentioned. People use to be made aware of pollution related health problems via mainstream media, but now all the news is restricted to Carbon emission palaver.
[Jan 2, 2011 12:12:22 PM]   Link   Report threatening or abusive post: please login first  Go to top 
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