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World Community Grid Forums
Category: Completed Research
Forum: FightAIDS@Home
Thread: A Few Questions on this Project |
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Thread Status: Active Total posts in this thread: 7
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
I just have a few questions for the scientist working on this project. How many molecules is going to be screened against the HIV protese protein during the life of this project? How many molecules those the program download during the day to day operation to screen? How long is this project going to last? When is the cancer project going to begin?
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
http://www.nlm.nih.gov/medlineplus/news/fullstory_28192.html
Dr. Olson says that Phase 1 will screen 2,000 compounds against 200 variant strains of HIV. The compounds are selected representatives of a number of different groups. AutoDock 4.0 is a new program for docking proteins, so there is not much that is cut-and-dried about this. Get the results, analyse them and then think a lot and decide where to go from there. Like most research programs, everything is negotiable depending on what is found. So the time it will take to do all this is uncertain. Of course, we can always quote Dr. Olson in his press release: "Three months."  mycrofth |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Grateful to the administrators that they respond and that too very fast to the queries. My question is - now that over 20 Million results have been arrived at, why not select the top 5 results and start clinical trials ? After some time, you can select again the top 5 results amongst all the results you got and then re-start the trials. This may save time.
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Thw 20,000,000 results you are referring to includes all of the results from the past year from the Protein Folding project. The Fight Aids At Home (FAAH) project just got started and only a small fraction of the 20,000,000 results belong to FAAH so most likely it will be a while before results from FAAH will be known. When you look at the statistics go into the "by project" area to get the actual number of completed workunits for FAAH.
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
There are currently 825.303 results returned for the FAAH project
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
That Medline article article and this thread make me wonder how much longer fa@h Phase 1 has to run.
If: - a result represents one molecule and one viral variant, and - each result will be calculated five times, and - the fa@h statistics can be extrapolated, then: Dr. Olson's Phase 1 will have finished at 2 million results by December 15th -- less than a third of the time predicted. I must be missing something. Does anyone here know what a "result" means in terms of the 2000 molecules and 200 mutations -- or how many times each result will be calculated? |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Hello sabbathcorn,
Until a project scientist explains, I cannot guess how many results will have to be run to check even one compound against one variety of HIV. On the last project, the Human Proteome Folding project (HPF), the folding algorithm worked off a random variable. We needed to fold each protein about 10,000 times to achieve statistical significance. Each work unit would fold the protein between 100 and 500 times. Reading over at Baker Lab (on Rosetta@home) I see that they prefer to fold a protein 100,000 times using a different version of Rosetta for some purposes. But like you, I realize that the math indicates we are going to make a number of trial runs for each compound - HIV variety. Otherwise we would be finished while still getting set up. mycrofth |
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