| Index | Recent Threads | Unanswered Threads | Who's Active | Guidelines | Search |
 |
World Community Grid Forums
Category: Active Research
Forum: OpenPandemics - COVID-19 Project
Thread: OpenPandemics - COVID-19 is Now Live |
| No member browsing this thread |
|
Thread Status: Active Thread Type: Sticky Thread Total posts in this thread: 282
|
|
| Author |
|
|
Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
The screensaver says protein target
https://www.worldcommunitygrid.org/help/viewS...e+when+OpenPandemics+–+CO |
||
|
|
Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
None of the above.....
Aren't we looking for binding energy in docking experiments? |
||
|
|
supdood
Senior Cruncher USA Joined: Aug 6, 2015 Post Count: 333 Status: Offline Project Badges: 
|
Robert--
----------------------------------------entity is correct: we are looking for binding energy to determine how a compound (ligand) would bind to a target (protein) on SARS-CoV2. The hope is that one or more of the 500 million compounds for which we are running the virtual docking experiments will bind in such a way to one of the target proteins so as to inhibit the functioning of SARS-CoV2. These compounds would then be used to develop therapeutic treatments. That is also part of the urgency here. There is a ton of work still to do to go from a good result in our virtual docking experiments to a usable therapeutic drug in the event that we find high-potential candidate compounds. ---------------------------------------- [Edit 1 times, last edit by supdood at May 21, 2020 1:12:19 PM] |
||
|
|
Applejacks
Cruncher Joined: Apr 21, 2017 Post Count: 6 Status: Offline Project Badges: 
|
Thanks for getting this up.
---------------------------------------- |
||
|
|
pgkerr
Cruncher Joined: Apr 28, 2007 Post Count: 2 Status: Offline Project Badges: 
|
 Great to have this up and running and hope we get good results soon. |
||
|
|
mrhowie
Cruncher Serbia Joined: May 17, 2020 Post Count: 1 Status: Offline Project Badges: 
|
Joined because of this
|
|||
|
||||
|
deltavee
Ace Cruncher Texas Hill Country Joined: Nov 17, 2004 Post Count: 4888 Status: Offline Project Badges: 
|
Joined because of this Hey mrhowie,Welcome to WCG and the Forums. |
||
|
|
oldDirty
Cruncher Joined: Mar 10, 2009 Post Count: 21 Status: Offline Project Badges: 
|
I join this after long time off WCG.
----------------------------------------I do hope, the benefits of this will be shared with all authorities worldwide, and not only AMERICA FIRST! Thx  [Edit 1 times, last edit by oldDirty at May 24, 2020 11:17:14 AM] |
||
|
|
yoerik
Senior Cruncher Canada Joined: Mar 24, 2020 Post Count: 413 Status: Offline Project Badges:
|
I join this after long time off WCG. I do hope, the benefits of this will be shared with all authorities worldwide, and not only AMERICA FIRST! Thx WCG's rules ensure that all data is made publicly available, to all. World Community Grid supports research that is: Humanitarian: Focused on solving problems to benefit humanity Not for profit: Conducted by public or nonprofit organizations Contributed to the public domain: all data generated by World Community Grid volunteers must be made freely available to the scientific community Accelerated by volunteer computing technology: computations that require significant computer processing power and can be divided into small independent computations  [Edit 1 times, last edit by yoerik at May 24, 2020 11:20:13 AM] |
||
|
|
CaffeinatedSloth
Advanced Cruncher United Kingdom Joined: Nov 12, 2014 Post Count: 80 Status: Offline Project Badges:
|
Robert-- entity is correct: we are looking for binding energy to determine how a compound (ligand) would bind to a target (protein) on SARS-CoV2. The hope is that one or more of the 500 million compounds for which we are running the virtual docking experiments will bind in such a way to one of the target proteins so as to inhibit the functioning of SARS-CoV2. These compounds would then be used to develop therapeutic treatments. That is also part of the urgency here. There is a ton of work still to do to go from a good result in our virtual docking experiments to a usable therapeutic drug in the event that we find high-potential candidate compounds. Given that we are searching over 500,000,000 compounds, am I right in thinking that one WU = 1 compounds? Therefore, it should take 500 million WUs (some having a quorum of 2 while computers become trusted, etc) to search through everything? Or is each compound broken into multiple WUs? Chris    |
||
|
|
|