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World Community Grid Forums
Category: Completed Research
Forum: FightAIDS@Home
Thread: Interesting news articles about AIDS |
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Thread Status: Active Total posts in this thread: 1122
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Dan60
Senior Cruncher Brazil Joined: Mar 29, 2006 Post Count: 185 Status: Offline Project Badges: 
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'Shock And Kill' Research Gives New Hope For HIV-1 Eradication
..."Cells harbouring a quiescent HIV genome are responsible for HIV persistence during therapy. In other words, HIV-1 genes become pieces of the human organism, and many scientists have simply thought there is nothing we can do. Dr Savarino's team aimed to 'smoke out' the virus in order to render the latently infected cells targetable by the immune system or artificial means." http://www.sciencedaily.com/releases/2009/06/090604095129.htm |
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Papa3
Senior Cruncher Joined: Apr 23, 2006 Post Count: 360 Status: Offline Project Badges: 
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http://www.sun-sentinel.com/news/local/breaki...-bn062209,0,6814790.story
Potential HIV breakthrough reported by Treasure Coast researchers Hillary Copsey | TCPalm.com 2:33 AM EDT, June 22, 2009 TRADITION - Researchers at biotech company VGTI Florida say they've [...] discovered a potential way to eradicate the human immunovirus that causes AIDS from the body. The findings were published online Sunday by Nature Medicine [http://www.nature.com/nm/journal/vaop/ncurrent/pdf/nm.1972.pdf] and will run in an upcoming print edition of the medical journal. Rafick-Pierre Sékaly, scientific director for VGTI Florida and a former scientist at the University of Montreal, is the senior author of the research paper. Sékaly and his team worked on determining why the anti-retroviral drugs, which are very effective in treating HIV and acquired immunodeficiency syndrome, do no completely rid the body of the virus. What they found is that HIV hides in the body's immune system, in T-cells capable of learning and memory. In these T-cells, the virus seems to multiply not by replicating itself, as it does in other places, but by staying in both parts of the cell when it divides. The paper suggests doctors could eradicate HIV in the body by both suppressing replication and stopping the division of memory T-cells. |
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Papa3
Senior Cruncher Joined: Apr 23, 2006 Post Count: 360 Status: Offline Project Badges:
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Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine?
Leonidas Stamatatos, Lynn Morris, Dennis R Burton & John R Mascola Most existing viral vaccines generate antibodies that either block initial infection or help eradicate the virus before it can cause disease. For HIV-1, obstacles to eliciting protective neutralizing antibodies (NAbs) have often seemed insurmountable. The target of HIV-specific NAbs, the viral envelope glycoprotein (Env), is highly variable in amino acid sequence and glycosylation pattern. Conserved elements of HIV-1 Env seem to be poorly immunogenic, and previous attempts to generate broadly reactive NAbs by vaccination have proven ineffective. However, recent studies show that antibodies in the sera of some HIV-1–infected individuals can neutralize diverse HIV-1 isolates. Detailed analyses of these sera provide new insights into the viral epitopes targeted by broadly reactive NAbs. The findings discussed here suggest that the natural NAb response to HIV-1 can inform future vaccine design. A concerted effort of structure-based vaccine design will help guide the development of improved antibody-based vaccines for HIV-1. Published online: 14 June 2009 | doi:10.1038/nm.1949 http://www.nature.com/nm/journal/vaop/ncurrent/pdf/nm.1949.pdf |
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Dan60
Senior Cruncher Brazil Joined: Mar 29, 2006 Post Count: 185 Status: Offline Project Badges:
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
HIV, AIDS rates: New website maps rates of infection
A national AIDS advocacy group, hoping to spark awareness of the regional impacts of the virus, has unveiled a new color-coded website that maps HIV/AIDS rates across the nation's localities, including bright red shading marking South Florida's very high rates. The National Minority Quality Forum unveiled the new HIV map last week. The map is at maphiv.org; information can be found at 202-223-7560. For local information: on HIV/AIDS, contact the Broward County Health Department at browardchd.org or 954-467-4700 or the Palm Beach County Health Department at pbchd.com or 561-840-4500. — Bob LaMendola maphiv.org; Welcome to the National HIV/AIDS Atlas The National HIV/AIDS Atlas provides a powerful new tool to the public, health care professionals, policy makers and elected officials to access and map local, state and national data in order to see how HIV/AIDS is impacting their community. What is the Atlas? For the first time, the Atlas presents county-level prevalence rates (based on the reported number of people living with HIV (non-AIDS) and AIDS in 2006) in all 50 states, the District of Columbia, Puerto Rico and the U.S. Virgin Islands, depicting the intensity of the disease, rather than the magnitude. |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
I just read this today. They are launching a phase 1 vaccine for human trials. I wonder if they used any of the information crunched by WCG for this?
http://communications.uwo.ca/com/western_news...milestone_20090702444563/ |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
Would not have a clue
Experimental HIV drugs restore health of artist, many others It's been nearly five years since Vancouver artist Tiko Kerr reluctantly stepped into the national spotlight to become the modern face of AIDS in Canada. At the time, Kerr's fight centred around his access -- or lack thereof -- to an experimental drug therapy that doctors in B.C. believed was the best and only chance to save his life, and the lives of other HIV-positive patients who had become immune to every other available treatment. Health Canada officials had initially denied the drugs in question on the grounds their safe use had not yet been scientifically proven. In a rare twist, this became an HIV story with a happy ending. After a 10-month standoff, the federal government relented under intense public pressure and in January 2006, Kerr and three other Vancouver men became the first patients in the country to test the new therapy..... |
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Papa3
Senior Cruncher Joined: Apr 23, 2006 Post Count: 360 Status: Offline Project Badges:
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http://www.washingtonpost.com/wp-dyn/content/...6/AR2009070602917_pf.html
HIV Positive..So Why Don't They Get AIDS? Researchers Hope 'Elite' Group Holds Clues for Others By Charles Slack Special to The Washington Post Tuesday, July 7, 2009 At first Karen Pancheau figured her son Tyler's nasty rash came from friction on the mats at judo class. But when the rash began dissolving layers of flesh, his father took the teenager for tests, which revealed he had HIV. Karen, too, tested positive for HIV, the virus that causes AIDS, which she'd apparently acquired from a blood transfusion in June 1982 and to which she'd exposed Tyler during childbirth and breast-feeding. Yet as Tyler's HIV slowly progressed to AIDS, Karen remained healthy. Various drug cocktails kept AIDS from killing Tyler, but they left him constantly fatigued, and on Nov. 11, 2005, the 23-year-old committed suicide. Remarkably, 27 years after receiving HIV-tainted blood, Karen Pancheau of Portland, Ore., has yet to develop AIDS. She isn't alone. Bruce Walker, who now directs the Partners AIDS Research Center at Massachusetts General Hospital and the Center for AIDS Research at Harvard University, first became aware in 1992 that some people seemed somehow protected from AIDS. He learned about the phenomenon from Susan Buchbinder, an epidemiologist in San Francisco who was analyzing blood from homosexual men whose samples showed they had been infected with HIV in the late 1970s; many had died, but some weren't even sick. Then, in 1994, Walker met a hemophiliac in Boston named Bob Massie, who had become infected with HIV through a blood transfusion in 1978 -- three years before AIDS was identified. "People keep telling me I'm going to die, and I keep living," Massie told Walker. A few years later, speaking before several hundred doctors at an AIDS conference in New York, Walker asked how many had run across similar patients. When at least half the audience raised their hands, Walker realized that people like Massie represented a real opportunity for research. Walker also understood why these rare individuals -- no more than one in every 300 cases, or perhaps 5,000 of the more than 1 million infected Americans -- had remained so well hidden: "They weren't sick. They weren't coming to the hospital." [...] |
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Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
IAVI, Theraclone Expand HIV Antibody Discovery Collaboration:
http://www.pharmaceutical-business-review.com...very_collaboration_090706 |
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Dan60
Senior Cruncher Brazil Joined: Mar 29, 2006 Post Count: 185 Status: Offline Project Badges:
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IAVI, Theraclone Expand HIV Antibody Discovery Collaboration: http://www.pharmaceutical-business-review.com...very_collaboration_090706 ..."To conduct his experiments, de Bakker uses powerful DNA scanners. Researchers deposit DNA samples on a "SNP chip" and insert it into a machine that produces color-coded maps of a person's DNA. Researchers can now examine as many as a million SNPs at once, but de Bakker thinks that within five years scanners will be able to compare the entire code of thousands of people. Somewhere in there, he thinks, will be clues to how elite controllers fend off AIDS." This news brings a lot of hope |
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