Index | Recent Threads | Unanswered Threads | Who's Active | Guidelines | Search |
![]() |
World Community Grid Forums
![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
No member browsing this thread |
Thread Status: Active Total posts in this thread: 78
|
![]() |
Author |
|
Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
http://bioverse.compbio.washington.edu/ which is practising genetic engineering (see summary): "A key paradigm in the Bioverse framework is to use sensitive homology detection based on sequence, structure and function to transfer information across organisms. (...) Since our Bioverse is not complete, i.e., we don't have all sequences encoded by all organismal genomes, to facilitate the internal cross-linking we have also created special databases consisting of sequences with particular properties (for examples, sequences with known three-dimensional structures, sequences in SWISS-PROT, etc.). Special biologically interesting collections will be provided." Just an accidental neighborhood ? Please let me clarify for you. In computational biology (bioinformatics), we use what is know for in one species to understand that which is not known for another. This is the transfer we speak of. This transfer is virtual, done with sequences in a computer. Experiments designed using the output data from you wonderful crunchers will not take one gene from one species and put it in another. We will not take a gene from a one strain of rice and put it in another. We will breed strains of rice together. Like dog breeders. Like farmers have been doing since farming was invented. Actually the transferability of information from one species to another is a foundation of biology research. Biologists use this concept through homologous genes, those genes / proteins in different species with the highest DNA / amino acid sequence similarity. Sadly, this is one of the reasons people do so much work on mice and other mammals, and lets not forget the poor yeast & bacteria too :-<. Nonetheless, what is true for mouse is often true for humans. We use knowledge based statistical models to apply all that science has created over the last 100+ years, from all species to rice, to speed up the experimental processes & avoid wasteful tooling around (i.e. create the best predictions possible before going to the lab). We have a huge focus on rice (as shown by this WCG project), but we also apply all our methods computationally to all species <http://bioverse.compbio.washington.edu>. Well, we cannot hope to model all of the protein structures for species in our other projects in the near future, this takes your massive computing power [thank you IBM]. But we do simulations to speed up research for all species, and these simulations have helped tremendously to avoid wastefulness in animals cost, time, etc. done by our collaborating experimentalists (<http://compbio.washington.edu/ongoing_research.html>): malaria, HIV, herpes, various infective bacteria (E coli, Mycoplama, Nitrosomonas), human, tooth regeneration, I would like to know: are the results from the new project (1) made for this purpose or possible (2) available like a waste-product for further use (patents) in the Bioverse-Department/Institute ? If so and i don´t want to hope for that, this is the backdoor for genetic engineering abusing a community with humanitarian requirements for commercial goals. The results from this project are not made for the purpose of genetic engineering. We do not do genetic engineering, our collaborators do not do genetic engineering. <http://compbio.washington.edu/papers/samudrala_2005a.pdf> I'm not certain what you mean by "available like a waste-product for further use (patents)." There will be no patents, this is all public domain. We seek to minimize waste as described above, and have made tremendous impact in this domain <http://compbio.washington.edu/papers/samudrala_2008a.pdf> In short: Does our crunching generate the basis for later patents ? Nope. Perhaps one ot the Group Members of the project is able to resolve all doubts in this direction by statement in these questions. So we can start crunching without pangs of conscience. We deeply appreciate your conscience. This is what drives us as well. We understand your concerns. If we didn't come along to do it right, it is possible that someone could try genetic engineering for rice. Its a great thing IBM came to help us do this & do it right! Since we have such a fantastic team working with us on this project <http://compbio.washington.edu/papers/samudrala_2005a.pdf>, with almost 10 continuous years of productive funding, WCG on our side, we are confident that no genetic engineering approach will do better. Rice is an incredibly complex system with more genes than humans; science has not yet figured out how to genetically engineer without messing them up, so using the tools of simple cross breading that ole' mother nature put in our hands will win out. Thanks for listening, no offense meant! X1900AIW :-> Thanks for participating and helping us to clarify these concerns for the others who might be concerned!!! Keep up the crunching! Peace and thanks, jeremy |
||
|
retsof
Former Community Advisor USA Joined: Jul 31, 2005 Post Count: 6824 Status: Offline Project Badges: ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() |
The more projects you take on, the less attention the desired project gets. Why even announce what projects WCG is working on? What is the incentive to join if it adds nothing significant to the project you care about? Individual projects will come and go. WCG does not do cancer all of the time or rice all of the time, or anything else all of the time. It depends on what finishes, what gets proposed, and what starts.Consider also the breakthroughs found in the computer programs themselves which require beta testing and fixing. The rice program deals with structures. Information gained in making these can also be used for other similar projects looking for structures. Many of the disease projects deal with 'docking', or trying to find a drug that has a physical structure that interferes with the host virus/germ or whatever. Better docking on one project can also help with a different one.
SUPPORT ADVISOR
Work+GPU i7 8700 12threads School i7 4770 8threads Default+GPU Ryzen 7 3700X 16threads Ryzen 7 3800X 16 threads Ryzen 9 3900X 24threads Home i7 3540M 4threads50% |
||
|
Sekerob
Ace Cruncher Joined: Jul 24, 2005 Post Count: 20043 Status: Offline |
A one stop shop AND these projects would hardly have happened if WCG had not invested millions into the hosting, free to the humanitarian project owners. NRW is time limited, 1 year approximately whilst several of the other projects are long running, often subdivided in many experiments like HPF2 and FA@H.
----------------------------------------(White text labels are projects in progress, black are complete or inactive) Thousands more have joined the World Community Grid force to work on common, yet so direly in need of solution needing problems: Nutritious Rice f/t World has done great so far, getting about a 1/6-1/5 of the overall daily growing volunteer contributions:
WCG
----------------------------------------Please help to make the Forums an enjoyable experience for All! [Edit 2 times, last edit by Sekerob at May 22, 2008 11:44:04 AM] |
||
|
Mr. Met
Cruncher Joined: May 16, 2008 Post Count: 19 Status: Offline |
If you want to help end world hunger, go to www.freerice.com
----------------------------------------
[URL=http://www.freerice.com][IMG]http://freerice.com/banners/392_72_FullBanner.jpg[/img][/URL]
|
||
|
Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
jeremy;
----------------------------------------It's a pity you have to handle these anti-GE anti-GM people with kid gloves. Not one in a hundred has clue one about what they're objecting to. ![]() **Edited for intolerance** [Edit 1 times, last edit by TKH at May 28, 2008 12:09:08 PM] |
||
|
Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
welcome me back to grid computing. it's been quite a while ...
|
||
|
Sekerob
Ace Cruncher Joined: Jul 24, 2005 Post Count: 20043 Status: Offline |
Yes JohnQ118, where were you with all the work to compute?
----------------------------------------Welcome back to volunteer crunching.
WCG
Please help to make the Forums an enjoyable experience for All! |
||
|
Former Member
Cruncher Joined: May 22, 2018 Post Count: 0 Status: Offline |
jeremy; It's a pity you have to handle these anti-GE anti-GM people with kid gloves. Not one in a hundred has clue one about what they're objecting to. ![]() **Edited for intolerance** ![]() ![]() |
||
|
|
![]() |