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Category: Active Research
Forum: Mapping Cancer Markers Forum
Thread: Interesting News Articles About Cancer |
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Thread Status: Active Total posts in this thread: 530
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[CSF] Thomas Dupont
Veteran Cruncher Joined: Aug 25, 2013 Post Count: 685 Status: Offline |
1- Well-known cancer gene NRAS produces 5 variants, study finds
----------------------------------------"The NRAS gene, known to play a fundamental role in cancer development, produces five gene variants, or isoforms, rather than just one form, as thought, new research shows. The study identified four previously unknown variants that the NRAS gene produces. The finding might help improve drugs for cancers in which NRAS plays a crucial role. It also suggests that NRAS might affect additional target molecules in cells." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 2- Hope for children with previously incurable brain cancer "Potential treatment targets for a previously incurable form of pediatric brain cancer called Diffuse Intrinsic Pontine Glioma has been revealed by scientists. The researchers believe that this discovery could lead to better treatment. "We're hoping that by having a better genetic characterization of these cancers we can try to better target these tumors and provide a personalized approach to treatment," one expert noted." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 3- Tissue testing during breast cancer lumpectomies prevents need for reoperation 96 percent of time "Unique laboratory testing during breast cancer lumpectomies to make sure surgeons remove all cancerous tissue spares patients the need for a repeat lumpectomy in roughly 96 percent of cases, a success rate much higher than the rate nationally, a study shows. During the years reviewed, 13.2 percent of breast cancer lumpectomy patients nationally had to return to the operating room within a month of their initial surgery, compared to 3.6 percent where these tests were performed." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 4- Gene sequencing project discovers mutations tied to deadly brain tumors in young children "New mutations in pediatric brain tumors known as high-grade gliomas, which most often occur in the youngest patients, have been discovered by researchers. The discoveries stem from the most comprehensive effort yet to identify the genetic missteps driving these deadly tumors. The results provide desperately needed drug development leads, particularly for agents that target the underlying mutations. This and other studies show these mutations often differ based on patient age." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 |
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[CSF] Thomas Dupont
Veteran Cruncher Joined: Aug 25, 2013 Post Count: 685 Status: Offline |
Cancer du cerveau de l'enfant : une piste de traitement génétique
----------------------------------------"La découverte d’anomalies sur un gène présent dans des tumeurs incurables du cerveau de l’enfant laisse espérer de nouvelles possibilités de traitements." http://www.sciencesetavenir.fr/sante/20140407...ment-genetique#xtor=EPR-6 |
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[CSF] Thomas Dupont
Veteran Cruncher Joined: Aug 25, 2013 Post Count: 685 Status: Offline |
CANCER de la BOUCHE : Des bains de bouche trop fréquents triplent le risque
----------------------------------------"De nombreuses marques de bains de bouche contiennent de l'alcool et leur utilisation trop fréquente pourrait augmenter le risque de cancer de la bouche, révèle cette étude multicentrique européenne qui a examiné la santé bucco-dentaire et l'hygiène dentaire de personnes atteintes de cancers de la bouche ou des voies aérodigestives supérieures. Les conclusions, présentées dans le Journal of Clinical Oncology confirment certes qu’une hygiène bucco-dentaire déficiente entraîne un risque accru, mais aussi, -sur un petit échantillon- que l’usage d’un bain de bouche plus de 3 fois par jour est associé à un risque multiplié par 3 de cancer des voies aérodigestives supérieures." http://www.santelog.com/news/cancerologie/can...relasuite.htm#lirelasuite MOUTH CANCER : Mouthwashes too frequent triple the risk "Many brands of mouthwashes contain alcohol and too frequent use may increase the risk of oral cancer, reveals this European multicenter study that examined the oral health and dental hygiene of people with cancer mouth or upper aerodigestive tract. Although the findings presented in the Journal of Clinical Oncology confirms that poor oral hygiene leads to an increased risk, but also, on a small sample, the use of a mouthwash more than 3 times per day is associated with a 3-fold increased risk of cancer of the upper aerodigestive tract." http://www.oraloncology.com/article/S1368-8375(14)00065-7/abstract French Article http://www.santelog.com/news/cancerologie/can...relasuite.htm#lirelasuite |
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[CSF] Thomas Dupont
Veteran Cruncher Joined: Aug 25, 2013 Post Count: 685 Status: Offline |
1- Blocking DNA repair mechanisms could improve radiation therapy for deadly brain cancer
----------------------------------------"In both cancer cell lines and in mice, blocking critical DNA repair mechanisms could improve the effectiveness of radiation therapy for highly fatal brain tumors called glioblastomas, research shows. Radiation therapy causes double-strand breaks in DNA that must be repaired for tumors to keep growing. Scientists have long theorized that if they could find a way to block repairs from being made, they could prevent tumors from growing or at least slow down the growth, thereby extending patients' survival." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 2- Potential therapeutic target for deadly brain cancer "New research identifies a potential characteristic for predicting outcome in a deadly form of brain cancer known as glioblastoma multiforme. Existing therapies based on genetic information have failed to effectively treat glioblastomas. Therefore, researchers are aggressively looking to find new molecular targets for this aggressive brain tumor." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 |
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[CSF] Thomas Dupont
Veteran Cruncher Joined: Aug 25, 2013 Post Count: 685 Status: Offline |
1- Bad penny : Cancer's thirst for copper can be targeted
----------------------------------------"Drugs used to block copper absorption for a rare genetic condition may find an additional use as a treatment for certain types of cancer, researchers report. The researchers found that cancers with a mutation in the BRAF gene require copper to promote tumor growth. These tumors include melanoma, the most dangerous form of skin cancer that kills an estimated 10,000 people in the United States a year, according to the National Cancer Institute." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 2- Cancer cells may respond to mechanical force "The processes and cellular pathways that allow cells to move, stiffen, and react to physical stresses has been identified through new research. This knowledge, researchers hope, could reveal the causes of cancer and help develop treatments, including therapies for a variety of diseases. "In the cancer context, mechanical force is important because tumor cells will generate force as they are invading, pulling on other cells," said one researcher. "They are pulling on the cells they are attached to as they are trying to get away." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 3- Chemotherapy may be better for certain patients with advanced lung cancer "Among patients with advanced non-small cell lung cancer without a mutation of a certain gene, conventional chemotherapy, compared with treatment using epidermal growth factor receptor tyrosine kinase inhibitors, was associated with improvement in survival without progression of the cancer, but not with overall survival, according to a study." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 4- Experimental drug shows promise for treatment-resistant leukemias "Research in mice and human cell lines has identified an experimental compound dubbed TTT-3002 as potentially one of the most potent drugs available to block genetic mutations in cancer cells blamed for some forms of treatment-resistant leukemia. Results show that two doses a day of TTT-3002 eliminated leukemia cells in a group of mice within 10 days. The treatment performed as well as or better than similar drugs in head-to-head comparisons." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 |
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[CSF] Thomas Dupont
Veteran Cruncher Joined: Aug 25, 2013 Post Count: 685 Status: Offline |
CANCER de la PEAU : De nouvelles variantes génétiques identifiées
----------------------------------------"Certaines mutations génétiques prédictives du risque de mélanome, sur un gène en particulier, POT1, viennent d’être identifiées par ce séquençage du matériel génétique de près de 200 personnes à antécédents familiaux de mélanome malin, la forme la plus grave de cancer de la peau. Ces nouvelles données, présentées dans la revue Nature Genetics constituent un nouveau pas vers l’identification précoce des familles à risque élevé de cancer de la peau." http://www.santelog.com/news/cancerologie/can...relasuite.htm#lirelasuite SKIN CANCER : New genetic variants identified "Some predictive genetic mutations in melanoma risk on a particular gene, POT1, come to be identified by sequencing the genetic material of nearly 200 people to a family history of malignant melanoma, the most serious form of skin cancer. These new data, presented in the journal Nature Genetics are another step towards the early identification of families at high risk of skin cancer." http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.2947.html French Article http://www.santelog.com/news/cancerologie/can...relasuite.htm#lirelasuite |
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[CSF] Thomas Dupont
Veteran Cruncher Joined: Aug 25, 2013 Post Count: 685 Status: Offline |
CANCER du POUMON : Les promesses d’un test sanguin ultrasensible
----------------------------------------"Détecter par test sanguin le cancer du poumon et diagnostiquer s’il est à stade avancé pourrait bientôt être possible, en analysant l'ADN des cellules tumorales mortes évacuées dans le sang. Dans cet essai, présenté dans la revue Nature Medicine, la technique, appelée CAPP-Seq pour cancer personalised profiling by deep sequencing semble efficace à détecter les toutes petites quantités d'ADN présentes dans le sang des personnes atteintes de cancer du poumon non à petites cellules." http://www.santelog.com/news/diagnostic/cance...relasuite.htm#lirelasuite LUNG CANCER : The promise of a blood test sensitivity "Detected by blood test lung cancer and diagnose if it is advanced may soon be possible, by analyzing the DNA of dead tumor cells in the blood evacuated. In this trial, presented in the journal Nature Medicine, the technique, called CAPP-Seq for cancer profiling by deep sequencing Personalised seems effective to detect very small amounts of DNA present in the blood of people with lung cancer, non-small cells." http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3519.html French Article http://www.santelog.com/news/diagnostic/cance...relasuite.htm#lirelasuite |
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[CSF] Thomas Dupont
Veteran Cruncher Joined: Aug 25, 2013 Post Count: 685 Status: Offline |
1- Brain cell discovery could open doors to targeted cancer therapies
----------------------------------------"Fresh insights into the processes that control brain cell production could pave the way for treatments for brain cancer and other brain-related disorders. Researchers have focused on a RNA molecule, known as miR-9, which is linked to the development of brain cells, known as neurons and glial cells. They have shown that a protein called Lin28a regulates the production of miR-9, which in turn controls the genes involved in brain cell development and function." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 2- Immunotherapy could help tackle tough liver cancer "Significant new data indicate that liver cancer may be treated by adoptive T cell therapy. This new therapeutic approach in the treatment of HCC could be very important as without treatment the 5 year survival rate is just 5%. Globally, HCC accounts for 746,000 deaths, and in the UK alone is responsible for over 4,000 deaths per year." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 3- 3-D printing cancer cells to mimic tumors "A 3-D model of a cancerous tumor using a 3-D printer has been successfully created by researchers. The model consists of a grid structure, 10 mm in width and length, made from gelatin, alginate and fibrin, which recreates the fibrous proteins that make up the extracellular matrix of a tumor. "With further understanding of these 3D models, we can use them to study the development, invasion, metastasis and treatment of cancer using specific cancer cells from patients. We can also use these models to test the efficacy and safety of new cancer treatment therapies and new cancer drugs," the lead author stated." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 4- New drug, molecular insight into triple negative breast cancers "Scientists have showcased a new drug active against triple-negative breast cancer, and through analysis of the drug's mechanism of action, offer increased understanding of the biology of this very aggressive form of breast cancer." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 |
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[CSF] Thomas Dupont
Veteran Cruncher Joined: Aug 25, 2013 Post Count: 685 Status: Offline |
CANCER de la PROSTATE : Le traiter sans risque d'incontinence ou d'impuissance
----------------------------------------"C’est une première mondiale et elle est française. Alors que le cancer de la prostate, le plus fréquent chez l’homme à partir de 50 ans, entraîne en France 8.000 décès par an, ce nouveau traitement par ultrasons focalisés est accueilli comme une alternative très prometteuse aux thérapies standards radicales, la chirurgie et la radiothérapie. D’autant que pour le patient, les bénéfices sont grands. Epargnant les tissus sains autour de la tumeur, les ultrasons du Focal One®, c’est son nom, réduisent au maximum les risques d’incontinence et d’impuissance." http://www.santelog.com/news/urologie/cancer-...relasuite.htm#lirelasuite |
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[CSF] Thomas Dupont
Veteran Cruncher Joined: Aug 25, 2013 Post Count: 685 Status: Offline |
1- Virus-fighting genes linked to mutations in cancer : Genetic evidence supports role of gene family in cancer development
----------------------------------------"All cancer-causing processes leave a distinct mutational imprint or signature on the genomes of patients. Researchers have found a major piece of biological evidence to support the role a group of virus-fighting genes has in cancer development. The mutational signature left by the cancer-causing process driven by this family of genes is found in half of all cancer types." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 2- Quarter of men drop out of prostate cancer monitoring, casting doubt on safety of 'active surveillance' "A long-term follow up of prostate cancer patients shows that the option of monitoring slow-growing prostate cancer may not be as safe as thought, due to a quarter of men dropping out of the monitoring program. Research shows that with advancing age, most men are likely to have a cancer of the prostate, although for many the cancer will be so slow growing that it does not create a real problem." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 3- Women with diabetes less likely to have a mammogram : Study "Women with diabetes are 14 percent less likely to be screened for breast cancer compared to women without diabetes, according to a study. "Managing the demands of a chronic condition such as diabetes is challenging for many women, leaving other preventative actions, like screening for cancer, to fall by the wayside," said a physician and author. "Our study found having diabetes posed a significant barrier to breast cancer screening even after considering a woman's socioeconomic status, a known contributor to disparities in care among women." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 4- Enzyme revealed as promising target to treat asthma, cancer "An enzyme involved in the regulation of immune system T cells that could be a useful target in treating asthma and boosting the effects of certain cancer therapies, report scientists, citing results of a recent mouse study. By untangling the different effects of SKG1, researchers have advanced efforts to fine-tune immune responses in patients. "We're not suppressing or exacerbating the immune system, we're regulating it," the lead author noted. "We're regulating it to do exactly what we want it to do." http://www.sciencedaily.com/releases/2014/04/...ily%3A+Top+Health+News%29 |
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