"Although we have a significant armament of therapeutic agents against HIV, factors that dictate the pharmacokinetics of anti-HIV drugs need to be accounted for in order to have HAART efficacy in sequestered viral reservoirs. Several P-gp inhibitors are currently under clinical trial, however, very little is being done to target the MRP-transporters. Our studies using the anti-HIV drugs, saquinavir and zidovudine, clearly implicated that inhibition of MRPs, rather than P-gp, would be a more beneficial approach to facilitate the entry of HAART drugs into the sub-endothelial reservoirs of HIV, especially within the brain. Unpublished findings from our laboratory suggest that, similar to MK-571, other leukotriene receptor antagonists, e.g. montelukast (SingulairTM) and zafirlukast (AccolateTM) can suppress MRP-mediated efflux of these anti-HIV drugs, as well. We believe that adjunct therapy with these clinically approved MRP inhibitors may improve HAART efficacy in HIV-positive patients, deter the selection of drug resistance and delay the progression of AIDS." Dr. Steve Goodman, Editor-in-Chief of Experimental Biology and Medicine said "this study by Dr. Mondal and colleagues has crucial implications in the persistence of sub-endothelial HIV reservoirs and will be important to the development of future therapies".