1- Towards new cancer therapies

"In 2012, about 8.2 million people died of cancer making the disease a major cause of death worldwide. According to the WHO World Cancer Report 2014, this figure is expected to rise within the next two decades. But new drugs are already in the pipeline. The genetics of fruit flies helps researchers to identify new targets for cancer therapy and to develop more individualised treatments."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

2- Limiting carbs could reduce breast cancer recurrence in women with positive IGF1 receptor

"Reducing carbohydrate intake could reduce the risk of breast cancer recurrence among women whose tumor tissue is positive for the IGF-1 receptor, researchers report. Using an unusual approach, this study assessed the combined association of two factors implicated in tumor growth -- carbohydrate intake and IGF1 receptor status -- to test whether activating the insulin/insulin-like growth-factor axis can impact breast cancer."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

3- Mammography has led to fewer late-stage breast cancers

"In the last 30 years, since mammography was introduced, late-stage breast cancer incidence has decreased by 37 percent, a new study finds. The analysis takes into account an observed underlying trend of increased breast cancer incidence present since the 1940s, a sort of inflation rate for breast cancer."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

4- Compact proton therapy for fight against cancer

"The future face of modern-day anti-cancer therapy based on charged particles like protons could potentially involve using laser accelerators. However, these facilities will need to be reduced in terms of both size and cost compared to conventional ones. A medical physicist is the first to present a new design for the entire complex machine – from the accelerator to the radiation site. In the process, he has successfully cut the facility's size in half."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

5- Guidelines address long-term needs of prostate cancer survivors

"Post-treatment clinical follow-up care for long-term and late effects faced by an estimated 2.8 million prostate cancer survivors in the United States is outlined in new clinical guidelines. The guidelines are designed to promote optimal health and quality of life for the posttreatment prostate cancer survivor by facilitating the delivery of comprehensive posttreatment care by primary care clinicians."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

6- Game changer for leukemia therapy may lead to less clinical treatment

"Researchers are zeroing in on a promising new approach to killing off cancer cells in patients with leukemia. Researchers have found that cancer cells decide whether to live or die after a short period of intense exposure to targeted therapy, opposing the current requirement for continuous treatment."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

7- What's the best test for cervical cancer ? Pap, HPV or both ?

"Should US women be screened for cervical cancer with Pap tests, HPV tests or both? According to researchers, while the merits of screening tests and screening intervals warrant further discussion, they firmly believe that increasing the number of women who participate in cancer screenings and ensuring that women are not lost to follow-up with lengthened screening intervals is more important than the choice of test to decrease rates of cervical cancer."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

8- Resistance to lung cancer targeted therapy can be reversed, study suggests

"Up to 40 percent of lung cancer patients do not respond to a targeted therapy designed to block tumor growth -- a puzzling clinical setback that researchers have long tried to solve. Now, scientists have discovered why that intrinsic resistance occurs -- and they pinpoint a drug they say could potentially reverse it."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

9- Needle biopsy underused in breast cancer diagnosis, negatively impacting diagnosis and care

"Needle biopsy, the standard of care radiological procedure for diagnosing breast cancer, is underused with too many patients undergoing the more invasive, excisional biopsy to detect their disease, according to research. The study also finds that patients are often influenced by surgeons to undergo the unnecessary surgery -- a decision that's costly and can negatively impact their diagnosis and treatment."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

10- Lifetime cancer risk from heart imaging low for most children, but rises with more complex tests

"Children with heart disease are exposed to low levels of radiation during X-rays, which do not significantly raise their lifetime cancer risk. However, children who undergo repeated complex imaging tests that deliver higher doses of radiation may have a slightly increased lifetime risk of cancer, according to researchers."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

CANCER du SEIN : La viande rouge associée au risque chez les femmes jeunes

"Les femmes jeunes ont tout intérêt à limiter leur consommation de viande rouge. Déjà liée, en cas d’apport trop important, à différents cancers, troubles métaboliques et cardiovasculaires, la consommation de viande rouge est associée, avec cette étude de Harvard, menée sur près de 90.000 femmes, au cancer du sein chez la femme jeune. Les conclusions, publiées dans le British Medical Journal, engagent les femmes à privilégier d’autres sources de protéines, comme le poulet, les noix ou les lentilles."

http://www.santelog.com/news/cancerologie/can...relasuite.htm#lirelasuite

BREAST CANCER : Red meat associated with risk in young women

"Young women have an interest to limit their consumption of red meat. Already bound in case of excessive intake, various cancers, cardiovascular and metabolic disorders, consumption of red meat is associated with the Harvard study conducted on nearly 90,000 women with breast cancer in young women. The findings, published in the British Medical Journal, women undertake in favor of other sources of protein such as chicken, nuts or lentils."

http://www.bmj.com/content/348/bmj.g3437.pdf+html

French Article
http://www.santelog.com/news/cancerologie/can...relasuite.htm#lirelasuite

1- Cellular complexity of brain tumors charted

"Scientists have conducted a first-of-its-kind study that characterizes the cellular diversity within glioblastoma tumors from patients. The study, which looked at the expression of thousands of genes in individual cells from patient tumors, revealed that the cellular makeup of each tumor is more heterogeneous than previously suspected."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

2- Advanced breast cancer : Benefits of Trastuzumab (Herceptin) outweigh the risk of harm

"In women with advanced (or metastatic) breast cancer, treatment with the breast cancer drug Trastuzumab (Herceptin) is associated with prolonged survival but also increases the risk of developing heart problems, a new systematic review shows. However, the review concludes that more women benefit from use of Trastuzumab than are harmed."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

1- Tugging on the 'malignant' switch in breast cancer

"A possible mechanism by which normal cells turn malignant in mammary epithelial tissues, the tissues frequently involved in breast cancer, has been discovered by researchers. Dense mammary tissue has long been recognized as a strong indicator of risk for breast cancer. This is why regular breast examinations are considered essential to early detection. Until now, however, the significance of that tissue density has been poorly understood."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

2- Most prostate cancer specialists don't recommend active surveillance for low-risk patients

"Specialists who treat prostate cancer agree that active surveillance is an effective option -- yet most don't recommend it when appropriate for their own patients, according to a study. Rather, urologists are more likely to recommend surgery and radiation oncologists are more likely to recommend radiation therapy -- the treatments provided by their own specialties."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

3- Lipids help to fight leukemia, study demonstrates

"T cells use a novel mechanism to fight leukemia. They may recognize unique lipids produced by cancer cells and kill tumor cells expressing these lipid molecules. A study now shows that a tumor-associated lipid stimulates specific T cells, which efficiently kill leukemia cells both in vitro and in animal models."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

4- Investing in cancer research boosts economy as well as health, experts say

"Money invested in cancer research generates a continuous stream of benefits, according to a report by three leading research institutions. Some of the greatest economic benefit was from efforts to reduce smoking rates, investment in breast cancer treatments, such as tamoxifen, and the cervical screening program."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

5- Nanoparticles aid microscopic detection of protein relevant for cancer

"Assemblies of proteins have important functions in cells. But because they are very small, their composition from subunits can only be determined indirectly or with extreme time-effort. Scientists are currently developing a novel microscopy technology for the direct detection of such individual subunits of protein complexes in the cell membrane of intact cells. The methodology is applied to investigate a protein complex acting as a calcium channel in the cell membrane. The channel plays an important role in prostate cancer."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

6- Breast cancer diagnosis, mammography improved by considering patient risk

"A new approach to examining mammograms that takes into account a woman's health risk profile would reduce the number of cancer instances missed and also cut the number of false positives, according to a paper. Providing radiologists with the patient's risk profile information for breast cancer at the most advantageous time when examining the mammogram , together with statistical weighting based on profile risk, reduces false negatives by 3.7%, thus alerting women whose cancer would have gone undiagnosed at an early stage, when treatment is most effective, research shows."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

7- Gene 'switch' reverses cancer in common childhood leukemia

"A type of leukaemia can be successfully 'reversed' by coaxing the cancer cells back into normal development, researchers have demonstrated. The discovery was made using a model of B-progenitor acute lymphoblastic leukaemia, the most common cancer affecting children. Researchers showed that switching off a gene called Pax5 could cause cancer in a model of B-ALL, while restoring its function could 'cure' the disease."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

8- Nanoshell shields foreign enzymes used to starve cancer cells from immune system

"A nanoshell to protect foreign enzymes used to starve cancer cells as part of chemotherapy has been developed by nanoengineers. Enzymes are naturally smart machines that are responsible for many complex functions and chemical reactions in biology. However, despite their huge potential, their use in medicine has been limited by the immune system, which is designed to attack foreign intruders."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

9- Genetic pathway can slow spread of ovarian cancer

"Research into the origins of ovarian cancer has led to the discovery of a genetic pathway that could slow the spread of the cancer. The discovery is in part due to research into the genetics of humans' most distant mammalian relative, the platypus."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

10- Low dose of targeted drug might improve cancer-killing virus therapy

"Giving low doses of the targeted agent bortezomib with a cancer-killing virus might improve the effectiveness of the virus as a treatment for cancer with little added toxicity. The findings support the testing of this combination therapy in a clinical trial."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

11- Sedentary behavior increases risk of certain cancers

"Physical inactivity has been linked with diabetes, obesity, and cardiovascular disease, but it can also increase the risk of certain cancers, according to a study. When the highest levels of sedentary behavior were compared to the lowest, the researchers found a statistically significantly higher risk for three types of cancer -- colon, endometrial, and lung."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

12- Gardens help cancer survivors cope, heal and grow

"Gardening helped cancer survivors eat better, get more exercise and improve physical function, a study concludes. Harvest for Health is a study that paired cancer survivors and master gardeners. The idea was to see if gardening would help survivors eat a more nutritious diet and improve physical activity."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

1- False negative results found in prognostic testing for breast cancer

"Researchers retested tumor samples from a large group of women and found that 22 out of 530 women had their tumor type incorrectly classified, which precluded them from effective treatment options. The repercussions of incorrectly identifying a cancer's subtype are considerable. "While it is comforting that only four percent of these women were misclassified initially, this is an enormous issue for those who fall into this group," said one researcher."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

2- Breathalyzer test may detect deadliest cancer

"Lung cancer causes more deaths in the US than the next three most common cancers combined. Now a new breathalyzer test, embedded with a 'NaNose' nanotech chip to literally 'sniff out' cancer tumors, has been developed by a team of international researchers. It may turn the tide by both accurately detecting lung cancer and identifying its stage of progression."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

3- No evidence that soy food protects against endometrial cancer, study finds

"No evidence of a protective association between soy food and endometrial cancer risk has been found, concludes a new study. Soy foods are an almost exclusive dietary source of isoflavones, a plant-derived estrogen. Some studies have highlighted their potential cancer protective properties, however, research looking at the link to endometrial cancer has been inconsistent."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

4- Vaccine 'reprograms' pancreatic cancers to respond to immunotherapy

"A vaccine that triggered the growth of immune cell nodules within pancreatic tumors, essentially reprogramming these intractable cancers and potentially making them vulnerable to immune-based therapies, has developed and tested by researchers. The reprogramming is designed to make the tumors more vulnerable to other immune-modulating drugs that have been useful in fighting other cancers, researchers explain."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

5- Survival compared for treatments of uncommon eye cancer

"In patients with advanced uveal melanoma, treatment with the agent selumetinib, compared with chemotherapy, resulted in an improved cancer progression-free survival time and tumor response rate, but no improvement in overall survival, according to a study. The modest improvement in clinical outcomes was accompanied by a high rate of adverse events."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

6- Treatment of bowel disease not linked with increased risk of cancer

"Use of a popular class of medications known as tumor necrosis factor alpha antagonists was not associated with an increased risk of cancer over a median follow-up of 3.7 years, according to a study that included more than 56,000 patients with inflammatory bowel disease. However, an increased risk of malignancy in the long term, or with increasing number of doses, cannot be excluded."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

7- Heparin derivative suppresses neuroblastoma tumor growth

"A new strategy for treating neuroblastoma using a modified version of heparin, a century-old injectable drug that thins the blood to prevent clots from forming, has been discovered by researchers. The study, conducted in mice, found that when heparin is altered to remove its blood-thinning properties, it can suppress and shrink neuroblastoma tumors without causing severe bleeding."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29