1- Gene mutation findings may lead to treatment for liver cancer

"Two genetic mutations in liver cells may drive tumor formation in intrahepatic cholangiocarcinoma (iCCA), the second most common form of liver cancer, researchers say. iCCA strikes bile ducts, tube-like structures in the liver that carry bile, which is required for the digestion of food. With so much still unknown about the disease, there is no first-line, standard of care and no successful therapies."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

2- Variations in key gene predict cancer patients' risk for radiation-induced toxicity

"Key genetic variants may affect how cancer patients respond to radiation treatments, according to a study. The current results are based on a genome-wide association study, a type of study in which researchers examine numerous genetic variants to see if any of them are associated with a certain type of complication, which could sometimes emerge years after treatment was completed."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

3- Possible pathway for inhibiting liver, colon cancer found

"The structure of a protein complex involved in liver and colon cancers has been revealed by an international team of researchers. This structural data discovery opens up additional research opportunities into drugs that can act on the binding of these proteins, thereby possibly inhibiting cancer cell growth."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

4- Low doses of arsenic cause cancer in male mice

"Mice exposed to low doses of arsenic in drinking water, similar to what some people might consume, developed lung cancer, researchers have found. Arsenic levels in public drinking water cannot exceed 10 parts per billion (ppb), which is the standard set by the U.S. Environmental Protection Agency. However, there are no established standards for private wells, from which millions of people get their drinking water."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

5- Chemotherapy resistance in inflammatory breast cancer due to newly identified mechanism

"A mechanism of breast cancer cells that leads to chemotherapy resistance in inflammatory breast cancer has been identified by researchers. Inflammatory breast cancer is the most aggressive type of advanced breast cancer and is characterized by rapid development, resistance to chemotherapy, early metastases and a poor prognosis. Inflammatory breast cancer cells display a triple-negative breast cancer phenotype that lacks the receptors needed to promote tumor growth. Therefore, common treatments are not effective for this breast cancer subtype."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

1- New therapeutic combination to slow resistant sarcomas

"A new therapeutic combination to combat resistant sarcomas have been tested in 19 patients in a recent study. The clinical trial results indicate that the new treatment could stabilize the growth of these tumors. Sarcomas are a rare type of tumor, and are complex since there are several subtypes. They can affect anyone from childhood onward."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

2- How antioxidants can accelerate cancers, and why they don't protect against them

"Two cancer researchers have proposed why antioxidant supplements might not be working to reduce cancer development, and why they may actually do more harm than good. Their insights are based on recent advances in the understanding of the system in our cells that establishes a natural balance between oxidizing and anti-oxidizing compounds. These compounds are involved in so-called redox (reduction and oxidation) reactions essential to cellular chemistry."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

3- Depressed men with prostate cancer are diagnosed with later stage disease, and get less effective therapies

"Depressed men with localized prostate cancer were more likely to be diagnosed with more aggressive prostate cancer, received less effective treatments and survived for shorter times than prostate cancer patients who were not depressed, a study has found."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

4- New drug active against most aggressive type of lung cancer cells

"A new drug could prove useful in treating small cell lung cancer -- the most aggressive form of lung cancer, researchers report. Scientists tested a drug -- known as AZD3965 -- on small cell lung cancer cells, with a focus on exploiting the change in energy production in tumors. In cancer cells, there is a switch to using glycolysis, a process that requires less oxygen and produces lactate as a by-product. Certain molecules -- monocarboxylate transporters (MCTs) -- are involved in the movement of lactate out of cells and drugs that target MCTs have been shown to stop tumor growth."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

5- The future of cancer research: In your medicine cabinet ?

"Where are the new low-cost cancer drugs? Do common drugs from the pharmacy represent the future of cancer treatment? Existing and widely-used non-cancer drugs may represent a relatively untapped source of novel therapies for cancer, new research suggests."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

6- Vasectomy may increase risk of aggressive prostate cancer

"Vasectomy was associated with a small increased risk of prostate cancer, and a stronger risk for advanced or lethal prostate cancer according to a new study. Vasectomy is a common form of contraception in the U.S., with about 15% of men having the procedure. Prostate cancer is the second-leading cause of cancer death among U.S. men, so identifying risk factors for lethal prostate cancer is important for public health."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

7- Protein found that pushes breast cancer cells to metastasize

"Using an innovative tool that captures heretofore hidden ways that cells are regulated, scientists have identified a protein that makes breast cancer cells more likely to metastasize. What's more, the protein appears to trigger cancer's spread in part by blocking two other proteins that are normally linked to neurodegeneration, a finding that suggests these two disease processes could have unexpected ties."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

8- Signal in may send cancer's cellular factories into overdrive

"A network of signals active in almost all types of cancer sends the protein factories in our cells into overdrive, and may help fuel a tumor's uncontrolled growth, new research suggests. The findings may help to explain how cancer cells maintain their high levels of metabolism -- and could uncover future targets for cancer treatment."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

1- New metastasis-suppressor gene identified by cancer researchers

"A new suppressor of cancer metastasis, FOXO4, has been identified by cancer researchers. Among patients with deadly cancers, more than 90 percent die because of metastatic spread of their disease. The new findings may point the way toward development of more effective treatments for prostate cancers and other malignant solid tumors."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

2- New method may allow breast cancer drug to be given through skin

"Endoxifen, a drug that has proven effective in the prevention and treatment of breast cancer, but with serious side-effects, may be delivered effectively through the skin using a new topical drug-delivery system. Endoxifen, one of the most commonly used hormone therapy for breast cancer, has also been shown to prevent the disease. However, taken orally, the drug can cause side-effects such as hot flashes and vaginal atrophy, along with increased risk of endometrial cancer and stroke, that leave it wanting as a routine method of chemoprevention."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

1- Prostate cancer in young men: More frequent, more aggressive?

"The number of younger men diagnosed with prostate cancer has increased nearly 6-fold in the last 20 years, and the disease is more likely to be aggressive in these younger men, according to a new analysis. Typically, prostate cancer occurs more frequently as men age into their 70s or 80s. However, the researchers found that when prostate cancer strikes at a younger age, it's likely because the tumor is growing quickly."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

2- Understanding melanoma development

"A new study shows how a genetic defect in a specific hormonal pathway may make people more susceptible to developing melanoma, the deadliest type of skin cancer. The study looked at the role of the melanocortin1 receptor (MC1R), the receptor on melanocytes in the skin that gets called into action following ultraviolet exposure to help the skin lay down more UV-blocking melanin to protect itself. Fair-skinned people are more likely to inherit a defect in this receptor, and as a result, cannot make enough melanin to fully protect themselves from UV damage."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

3- 'Game theory' model reveals vulnerable moments for metastatic cancer cells' energy production

"Cancer’s no game, but researchers are borrowing ideas from evolutionary game theory to learn how cells cooperate within a tumor to gather energy. Their experiments, they say, could identify the ideal time to disrupt metastatic cancer cell cooperation and make a tumor more vulnerable to anti-cancer drugs."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

4- Neurons, brain cancer cells require the same little-known protein for long-term survival

"Researchers show how the protein PARC/CUL9 helps neurons and brain cancer cells override the biochemical mechanisms that lead to cell death in most other cells."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

5- Does cat poop parasite play a role in curing cancer?

"From the litter box to the laboratory, a microscopic organism native to cats shows promise in treating cancer. Researchers’ mutated strain of T. gondii has been found to reprogram the natural power of the immune system to kill cells. Found worldwide, T. gondii affects about one-third of the world's population, 60 million of which are Americans."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

6- Cholesterol activates signaling pathway that promotes cancer, study shows

"Everyone knows that cholesterol, at least the bad kind, can cause heart disease and hardening of the arteries. Now, researchers describe a new role for cholesterol in the activation of a cellular signaling pathway that has been linked to cancer."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

7- Cancer patients: How strongly does tissue decelerate the therapeutic heavy ion beam?

"A method for the more exact dosing of heavy ion irradiation in the case of cancer has been developed by researchers. Research in this relatively new therapy method is focused again and again on the exact dosing: how must the radiation parameters be set in order to destroy the cancerous cells "on the spot" with as low a damage as possible to the surrounding tissue?"

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

8- Bonuses for doctors do little to improve cancer screening in Ontario

"Ontario spent nearly $110 million dollars between 2006 and 2010 on bonuses to motivate family doctors to screen more of their patients for cancer but these bonuses were associated with little or no improvement in actual cancer screening rates, according to researchers. "Governments around the world are experimenting with paying doctors extra to improve the quality of care but there's actually very little evidence that this strategy works," said the lead author."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

9- Innovative technique may transform hunt for new antibiotics, cancer therapies

"A new technique to quickly uncover novel, medically relevant products produced by bacteria has been developed by researchers. Past techniques involved screening more than 10,000 samples to find a novel product, but now researchers have discovered a novel product after screening just a few dozen soil bacteria by using this new technique."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

10- New route for ovarian cancer spread discovered

"Circulating tumor cells spread ovarian cancer through the bloodstream, homing in on a sheath of abdominal fatty tissue where it can grow and metastasize to other organs, scientists report. The researchers found the circulating tumor cells (CTCs) rely on HER3, a less-famous sibling of the HER2 receptor protein prominent in some breast cancers, to find their way to the omentum, a sheet of tissue that covers and supports abdominal organs."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

11- Is cancer avoidable as you grow older?

"Although it is widely thought that cancer is an inevitable consequence of aging, the risk of developing several common cancers decreases with age. A new protein biomarker test platform developed by researchers promises to improve diagnostic testing. The test can accurately and simultaneously measure multiple proteins that indicate the presence of diseases like graft-versus-host disease (bone marrow transplant rejection) in only two hours, no washing steps, and using only a minute volume of blood plasma."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

12- New theory turns cancer on its head: Does cancer form after cellular evolution?

"A new theory of how cancer works could lead to the next generation of treatments of the disease. The theory suggests that cancer forms when recently evolved genes are damaged, and cells have to revert to using older, inappropriate genetic pathways. "Our model suggests that cancer progression is the accumulation of damage to the more recently acquired genes. Without the regulation of these recent genes, cell physiology reverts to earlier programs, such as unregulated cell proliferation," researchers explain."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

13- Breast cancer: Disease management program is largely consistent with guidelines

"There are only few discrepancies between the disease management program for breast cancer and current guidelines. However, some of the guidelines are more detailed. A need for revision may arise if new studies provide new evidence on a disease and its treatment."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

14- Self-assembling nanoparticle could improve MRI scanning for cancer diagnosis

"A new self-assembling nanoparticle has been developed that targets tumors, to help doctors diagnose cancer earlier. The new nanoparticle boosts the effectiveness of MRI scanning by specifically seeking out receptors that are found in cancerous cells. The nanoparticle is coated with a special protein that looks for specific signals given off by tumors. When it finds one, it begins to interact with the cancerous cells; this interaction strips off the protein coating, causing the nanoparticle to self-assemble into a much larger particle so that it is more visible on the scan."

http://www.sciencedaily.com/releases/2014/07/...ily%3A+Top+Health+News%29

CANCER du SEIN : Un gel transdermique à base de tamoxifène pour préserver la fertilité

"Une efficacité selon ce premier essai comparable après 10 semaines d'application, ce gel à base de tamoxifène pourrait bien concurrencer le même traitement par voie orale, mais avec un risque bien diminué de caillot sanguin. Les résultats de cet essai, mené à la Northwestern et présenté dans la revue Clinical Cancer Research, montrent en effet que ce gel, appliqué directement sur les seins de patientes atteintes de cancer du sein non invasif réduit la croissance des cellules cancéreuses au même degré que le médicament pris sous forme orale, mais avec moins d'effets secondaires."

http://www.santelog.com/news/cancerologie/can...relasuite.htm#lirelasuite

BREAST CANCER : A transdermal gel containing tamoxifen

"Efficiency in this first test comparable after 10 weeks of application, based gel tamoxifen could compete on the same oral treatment, but with a much reduced risk of blood clot. The results of this trial, conducted at Northwestern and presented in the journal Clinical Cancer Research, show that this gel applied directly to the breasts of patients with non-invasive breast cancer reduces the growth of cancer cells to the same degree that the drug taken orally, but with fewer side effects."

http://clincancerres.aacrjournals.org/content...e7-4397-8ff3-b5da6e6512c7

French Article
http://www.santelog.com/news/cancerologie/can...relasuite.htm#lirelasuite