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[CSF] Thomas Dupont
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News L

CRÈME SOLAIRE : Efficace aussi dans la prévention du mélanome ?

"On est certain que choisi et utilisé de manière adaptée, un écran solaire est efficace pour prévenir les coups de soleil, mais l’est-il dans la prévention du mélanome ? Cette recherche menée à l'Institut de recherche biomédicale au Texas, publiée dans la revue Pigment Cell and Melanoma établit, sur l’animal et sans équivoque, que l'incidence du mélanome malin à l'âge adulte peut être considérablement réduite par une utilisation régulière et adaptée de crème solaire dans la petite enfance et l'enfance. Des données qui ne doivent pas faire oublier que les écrans solaires, même haute protection, ne sont qu’une des mesures à prendre, en particulier pour les enfants, contre le risque de brûlure et de mélanome."

http://www.santelog.com/news/cancerologie/cre...relasuite.htm#lirelasuite

SUNSCREEN : As effective in preventing melanoma ?

"It is certain that selected and used appropriately, sunscreen is effective in preventing sunburn, but is it in preventing melanoma ? This research conducted at the Institute of Biomedical Research in Texas, published in the journal Pigment Cell and Melanoma establishes animal and unequivocally that the incidence of malignant melanoma in adulthood can be significantly reduced by use regular and appropriate sunscreen in infancy and childhood. Data that must not forget that sunscreen, even high protection, are only steps to take, especially for children, against the risk of burns and melanoma."

http://onlinelibrary.wiley.com/doi/10.1111/pcmr.12283/abstract

French Article
http://www.santelog.com/news/cancerologie/cre...relasuite.htm#lirelasuite
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[CSF] Thomas Dupont
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News LI

1- For cancer patients, new tool predicts financial pain

"Cancer care has a new side effect. Along with the distress of a cancer diagnosis and the discomforts of treatment, patients now have to deal with “financial toxicity,” the expense and anxiety confronting those who face large, unpredictable costs, often compounded by decreased ability to work. The cost of health care in the United States is rising faster than the gross domestic product. The cost of cancer care is rising faster than the cost of health care, and the cost of new cancer drugs is rising faster than the cost of overall cancer care."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

2- Shorter time to first cigarette of the day is associated with risk of lung cancer

"Standard markers of nicotine dependency include cigarettes smoked per day, duration of smoking, and cumulative exposure (pack years), but another marker of addiction, time to first cigarette of the day, may also be associated with the risk of getting lung cancer in both heavy and light smokers, according to a study."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

3- Better imager for identifying tumors

"A new technique that could improve surgeons' ability to identify cancerous tumors and remove them in real-time in the operating room has been developed by researchers. The new imaging system combines two techniques -- near-IR fluorescent imaging and visible light reflectance imaging -- to get a much better picture of the tissue."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

4- New tool to confront lung cancer focuses on misregulation of two genes

"Misregulation of two genes, sox2 and lkb1, drives squamous cell lung cancer in mice, researchers report. The discovery uncovers new treatment strategies, and provides a clinically relevant mouse model in which to test them. Only 15% of patients with squamous cell lung cancer -- the second most common lung cancer -- survive five years past diagnosis. Little is understood about how the deadly disease arises, preventing development of targeted therapies that could serve as a second line of defense once standard chemotherapy regimens fail."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

5- Racial disparities in sentinel lymph node biopsy in women with breast cancer

"The use of sentinel lymph node biopsy to stage early breast cancer increased in both black and white women from 2002 to 2007, but the rates remained lower in black than white patients, a disparity that contributed to disparities in the risk for lymphedema (arm swelling common after breast cancer treatment because of damage to the lymphatic system)."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29
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[CSF] Thomas Dupont
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News LII

1- Telephone call is effective support when breast cancer treatment includes weight loss

"A series of simple telephone calls can make a profound difference in helping women to meet their treatment goals for breast cancer, according to a randomized trial of women who are also obese. Women who received advice about weight loss from a trained lifestyle coach by telephone achieved weight loss that was still evident after two years, lowering their risk of breast cancer recurrence."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

2- Possible new combination treatment for cancer

"A new cancer treatment has been developed that has proved to be effective in mice. The treatment is based on newly discovered properties of the so-called BET bromodomain inhibitors. "The work is challenging, but we believe that the prospects for success with combination treatments are good," says the lead investigator."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

3- Anti-androgen therapy for triple-negative breast cancer may benefit lower-androgen tumors

"Even triple negative breast cancers expressing very low levels of androgen receptor may benefit from anti-androgen therapy, researchers report. "This line of work is starting to change our thinking about who and when -- the timing and patient selection for anti-androgen receptor therapy in triple-negative breast cancer," says the study's first author."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

4- BPA stimulates growth of an advanced subtype of human breast cancer cells called inflammatory breast cancer

"Environmental exposure to the industrial chemical bisphenol A (BPA) lowers the effectiveness of a targeted anti-cancer drug for inflammatory breast cancer, according to a new study. The results also show that BPA causes breast cancer cells to grow faster."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

5- Cancer by remote-control : Overlooked DNA shuffling drives deadly paediatric brain tumour

"One of the deadliest forms of paediatric brain tumor, Group 3 medulloblastoma, is linked to a variety of large-scale DNA rearrangements which all have the same overall effect on specific genes located on different chromosomes. "We were surprised to see that in addition to MYC there are two other major drivers of Group 3 medulloblastoma -- two sister genes called GFI1B and GFI1," says Korbel. "Our findings could be relevant for research on other cancers, as we discovered that those genes had been activated in a way that cancer researchers don't usually look for in solid tumors," researchers remarked."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

6- Family dysfunction strong predictor of emotional problems in children of cancer patients

"A cancer diagnosis affects the whole family, and a significant number of children of cancer patients may be at risk for emotional and behavioral problems. New research suggests that family dysfunction may increase a child's risk of experiencing such problems after learning of a parent's illness. "This means that in view of a life-threatening disease in a parent, the level of family functioning predicts children's behavioral and emotional symptoms more than any other tested variable including illness-related factors," the lead author explained."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

7- Colon has safety mechanism that restricts tumor formation

"Colon cancer development starts with the formation of benign tumors called adenomas. It is estimated that between 30% and 50% of people over 50 will develop one of these tumors. These adenomas or polyps are the pre-cancerous lesions that, once they accumulate further genetic mutations over many years, can progress to colon cancer. A team has discovered that the colon has a safety mechanism to restrict the formation and growth of adenomas."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

8- Potential avenues for treatment of deadly nasopharyngeal cancer discovered

"A distinct mutational signature and nine significantly mutated genes associated with nasopharyngeal cancer have been found by an international team of researchers, paving the way to developing novel therapies for this deadly disease. The group has conducted the first successful comprehensive genomic study of nasopharyngeal carcinoma, which has a particularly high prevalence in Southern China and Southeast Asia, including Singapore. The findings provide an enhanced road map for the study of the molecular basis of this form of cancer."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

9- Easing pain, getting back quality of life for cancer survivors

"More and more people are surviving their cancer but they don't need to cope with lingering pain in silence. A review paper now describes what survivors can do to improve their quality of life. “Pain makes people less functional,” says one author. “I think the key thing people need to know is to ask for help if they have chronic pain after cancer. They need to know that there are lots of different ways to address pain. Just because the cancer is gone doesn’t mean you’re going to be 100 percent the way you were before you were treated.” Survivors shouldn’t suffer in silence."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

10- Starving pancreatic cancer before it has a chance to feast

"Researchers are working towards cutting off the growth of pancreatic tumors before they can metastasize throughout the body. Pancreatic cancer and other cancers can only thrive, grow and spread if they have nutrients from blood, just like other tissues in our bodies. Cancer cells and tumors at first rely on nearby blood vessels to get what they need to survive, but, as tumors grow, they need to form new vessels. These vessels differ from those in regular tissue, Sushanta explained, which is part of the reason cancer can be so difficult to treat."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29
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[CSF] Thomas Dupont
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News LIII

1- Role of cohesin in cancer revised by researcher

"The role of cohesin, iPts regulation, as well as its recently identified function as a potential driver or facilitator for tumors has been explained and revised by an international expert in cohesin. The challenge now is to understand the link between cohesin and the development and evolution of cancer, an area where there is currently little data."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

2- Virus kills triple negative breast cancer cells, tumor cells in mice

"A virus not known to cause disease kills triple-negative breast cancer cells and killed tumors grown from these cells in mice, according to researchers. Understanding how the virus kills cancer may lead to new treatments for breast cancer. "These results are significant, since tumor necrosis -- or death -- in response to therapy is also used as the measure of an effective chemotherapeutic," one researcher said."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

3- Cell division discovery could optimize timing of chemotherapy, explain some cancers

"A new study has been able to demonstrate how the cycle of cell division in mammalian cells synchronizes with the body's own daily rhythm, its circadian clock. The study not only helps to explain why people with sustained disrupted circadian rhythms can be more susceptible to cancer, it may also help establish the optimal time of day to administer chemotherapy."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

4- New possibilities for leukemia therapy with novel mode of leukemia cell recognition

"A new class of lipids in the leukemia cells that are detected by a unique group of immune cells has been discovered by researchers. By recognizing the lipids, the immune cells stimulate an immune response to destroy the leukemia cells and suppress their growth. The newly identified mode of cancer cell recognition by the immune system opens up new possibilities for leukemia immunotherapy."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

5- Gene in brain linked to kidney cancer, researchers say

"A gene known to control brain growth and development is heavily involved in promoting clear cell renal cell carcinoma, the most common form of kidney cancer, researchers are reporting. The research reveals that the gene NPTX2, plays an essential role in this cancer type, which is resistant to common chemotherapy and has a five-year overall survival rate of less than 10 percent in patients with metastatic disease."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

6- Potential new treatment approach for lung cancer

"More than a third of all human cancers are driven by mutations in a family of genes known as Ras. Ras has long been considered to be a target that does not respond to cancer treating drugs, but recent research suggests new possibilities. Investigators have demonstrated that targeting a metabolic dependency downstream of Ras could provide therapeutic benefit to patients with Ras-driven lung cancers."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

7- Cancer 'as old as multi-cellular life on Earth': Researchers discover a primordial cancer in a primitive animal

"Can cancer ever be completely defeated? Researchers have now reached a sobering conclusion: "cancer is as old as multi-cellular life on Earth and will probably never be completely eradicated," says one expert, following his latest research results. The researchers have now achieved an impressive understanding of the roots of cancer, providing proof that tumors indeed exist in primitive and evolutionary old animals."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

8- Young indoor tanning increases early risk of skin cancer

"Early exposure to the ultraviolet radiation lamps used for indoor tanning is related to an increased risk of developing basal cell carcinomas (BCC) at a young age, researchers confirm. Since indoor tanning has become increasingly popular among adolescents and young adults, this research calls attention to the importance of counseling young people about the risk of indoor tanning. The study notes that indoor tanning products can produce 10 to 15 times as much UV radiation as the midday sun."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

9- Cancer chain in cell membrane seen with supercomputers

"Supercomputer simulations reveal clusters of a protein linked to cancer warp cell membranes -- findings could help design new anticancer drugs. Researchers used XSEDE/TACC supercomputers Lonestar and Stampede to simulate molecular dynamics of Ras protein clusters at the cell membrane. Simulations give greater understanding of Ras protein role in cancer and provide models for further experimental tests."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

10- Possible answer to chemo pain found in multiple sclerosis drug

"Two discoveries have been described by researchers: a molecular pathway by which a painful chemotherapy side effect happens and a drug that may be able to stop it. "The chemotherapy drug paclitaxel is widely used to treat many forms of cancer, including breast, ovarian and lung cancers," said one researcher. "Though it is highly effective, the medication, like many other chemotherapy drugs, frequently is accompanied by a debilitating side effect called chemotherapy induced peripheral neuropathy, or CIPN."."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29
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[CSF] Thomas Dupont
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News LIV

1- Adding element to standard treatment in post-gemcitabine metastatic pancreatic cancer improves survival

"Adding the novel MM-398 to standard treatment for metastatic pancreatic cancer patients who have already received gemcitabine improves survival, researchers have said. "One of the biggest challenges in pancreatic cancer is drug delivery. "MM-398 (nal-IRI) is a nanoliposomal irinotecan: this delivery system allows longer drug exposure in the circulation and more accumulation of the drug and its active metabolite SN38 at the tumor site," said one author."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

2- Master regulator of key cancer gene found, offers new drug target

"A key cancer-causing gene, responsible for up to 20 percent of cancers, may have a weak spot in its armor, according to new research. The partnership of MYC, a gene long linked to cancer, and a non-coding RNA, PVT1, could be the key to understanding how MYC fuels cancer cells."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

3- New device could improve biomarker analyses

"A new devise could offer a more reliable alternative for detecting biomarkers in patients facing such illnesses as cancer or malaria. Whether to extract circulating tumor cells from the blood of a cancer patient, or to measure the elasticity of red blood cells due to malaria infection, the physical attributes of cells are important biomarkers in medicine."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

4- Study of over 450,000 women finds 3-D mammography detects more invasive cancers and reduces call-back rates

"Researchers have found that 3D mammography —- known as digital breast tomosynthesis —- found significantly more invasive, or potentially lethal, cancers than a traditional mammogram alone and reduced call-backs for additional imaging."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

5- Synthetic triterpenoids show promise in preventing colitis-associated colon cancer

"A class of small antioxidant molecules carries enormous promise for suppressing colon cancer associated with colitis. These findings offer hope that physicians ultimately will be able to reduce dramatically the number of sufferers of this inflammatory bowel disease (IBD) who go on to develop colon cancer."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29
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[CSF] Thomas Dupont
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News LV

CANCER du CERVEAU : 5 mythes à abattre

"Ces experts encouragent, avec cet article, à paraître dans l’édition de juillet de la revue Neurosurgery à une nouvelle vision et à de nouvelles stratégies dans la lutte contre le cancer du cerveau, rejetant le pessimisme ambiant et certains mythes liés à sa prise en charge. Ils recommandent la prise en compte des données et des outils actuels de la science pour optimiser la prise en charge de ces patients. Un rappel de l'opportunité des traitements personnalisés."

http://www.santelog.com/news/neurologie-psych...relasuite.htm#lirelasuite

BRAIN CANCER : 5 myths down

"These experts are encouraging, with this article, to be published in the July issue of the journal Neurosurgery in a new vision and new strategies in the fight against brain cancer, rejecting pessimism and some myths related to its management supported. They recommend taking into account current data and tools of science to optimize the management of these patients. A reminder of the opportunity of personalized treatments."

http://journals.lww.com/neurosurgery/Abstract..._the_Management_of.1.aspx

French Article
http://www.santelog.com/news/neurologie-psych...relasuite.htm#lirelasuite
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News LVI

1- Researchers hone in on way to predict aggressiveness of oral cancer

"Studying mouth cancer in mice, researchers have found a way to predict the aggressiveness of similar tumors in people, an early step toward a diagnostic test that could guide treatment, according to researchers. The investigators found a consistent pattern of gene expression associated with tumor spreading in mice. Analyzing genetic data from human oral cancer samples, they also found this gene signature in people with aggressive metastatic tumors."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

2- Continued use of low-dose aspirin may lower pancreatic cancer risk

"The longer a person took low-dose aspirin, the lower his or her risk for developing pancreatic cancer, according to a study recently published. Men and women who took low-dose aspirin regularly had 48 percent reduction in their risk for developing pancreatic cancer. Protection against pancreatic cancer ranged from 39 percent reduction in risk for those who took low-dose aspirin for six years or less, to 60 percent reduction in risk for those who took low-dose aspirin for more than 10 years."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29
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[CSF] Thomas Dupont
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News LVII

1- Some aggressive cancers may respond to anti-inflammatory drugs

"Some cancer patients with aggressive tumors may benefit from a class of anti-inflammatory drugs used to treat rheumatoid arthritis, new research suggests. Studying triple-negative breast cancer, researchers found that some aggressive tumors rely on an antiviral pathway that appears to drive inflammation, widely recognized for roles in cancer, rheumatoid arthritis and other inflammatory diseases."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

2- Genetics the dominant risk factor in common cancers

"A study of individuals who have been adopted has identified genetics as the dominant risk factor in ‘familial’ breast, prostate and colorectal cancers. Researchers have presented the new research findings based on studies of population registers.“The results of our study do not mean that an individual’s lifestyle is not important for the individual’s risk of developing cancer, but it suggests that the risk for the three most common types of cancer is dependent to a greater extent on genetics”, said the lead of the study."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

3- Comprehensive review of treatments for depression in cancer patients

"When depression co-exists with cancer, patients may be at an increased risk of death from cancer and from suicide. Antidepressants are commonly prescribed, but the evidence on their efficacy is mixed. The role of antidepressants in treating cancer-related depression has not been rigorously studied. To identify best practice for the treatment of depression in cancer, researchers completed a systematic review and meta-analysis of existing research."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29
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News LVIII

CANCER du SEIN : Un test sanguin ?

"Des tests sanguins de risque génétique de cancer du sein existent déjà. Ils vont principalement rechercher des mutations dans le gène BRCA et peuvent être utilisés chez les femmes à antécédents familiaux de cancer du sein. Mais ce nouveau test pourrait détecter de manière précoce le risque non génétique de cancer du sein. Ces travaux britanniques, publié dans la revue Genome Medicine, suggèrent même, déjà à ce stade, un bon degré de précision."

http://www.santelog.com/news/diagnostic/cance...relasuite.htm#lirelasuite

New test predicts risk of non-hereditary breast cancer

"A simple blood test is currently in development that could help predict the likelihood of a woman developing breast cancer, even in the absence of a high-risk BRCA1 gene mutation, according to research. Researchers identified an epigenetic signature in the blood of women predisposed for breast cancer. Strikingly, the same signature was discovered in the blood of women without a BRCA1 mutation but who went on to develop breast cancer, making it a potential early marker of women's cancer in the general population."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29
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News LIX

1- Cetuximab or bevacizumab with combi chemo equivalent in KRAS wild-type MCRC

"For patients with KRAS wild-type untreated colorectal cancer, adding cetuximab or bevacizumab to combination chemotherapy offers equivalent survival, researchers said."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29

2- Phase III trial shows improved survival with TAS-102 in metastatic colorectal cancer refractory to standard therapies

"The new combination agent TAS-102 is able to improve overall survival compared to placebo in patients whose metastatic colorectal cancer is refractory to standard therapies, researchers said."

http://www.sciencedaily.com/releases/2014/06/...ily%3A+Top+Health+News%29
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